Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.31 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2113416 | 0.89 | CYP3A4 (0.56) | CYP3A4CRBNADRB1LMNAKDM4E | |
| SCHEMBL2915585 | 0.88 | CYP3A4 (0.43) | CYP3A4CRBNADRB1LMNANPC1 | |
| SCHEMBL2916119 | 0.87 | ALOX12 (0.37) | CYP3A4ALOX12ADRB1NTRK1 | |
| SCHEMBL2915218 | 0.86 | CYP3A4 (0.40) | CYP3A4CRBNADRB1 | |
| SCHEMBL2915916 | 0.82 | CRBN (0.39) | CYP3A4CRBNADRB1NPSR1NPC1 | |
| SCHEMBL2913728 | 0.81 | CYP3A4 (0.56) | CYP3A4CRBN | |
| SCHEMBL2915572 | 0.81 | CRBN (0.40) | CYP3A4CRBNADRB1 | |
| SCHEMBL2913880 | 0.81 | CYP3A4 (0.56) | CYP3A4CRBN | |
| SCHEMBL2914859 | 0.81 | CYP3A4 (0.40) | CYP3A4CRBNADRB1ABCB1 | |
| SCHEMBL2914788 | 0.80 | CRBN (0.39) | CYP3A4CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222646-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | Abbott Laboratories (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009039127-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | ABBOTT LABORATORIES (US) | 2009-03-26 | — | — | WO | disclosed |