SCHEMBL29152129

SCHEMBL29152129

N#Cc1c2ccccc2c(-c2ccc(C(F)(F)F)cc2)c2ccccc12

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 7/20 0.50
ALDH1A1 P00352 4/20 0.48
MAPT P10636 2/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
TDP1 Q9NUW8 1/20 0.48
ADORA1 P30542 1/20 0.41
ESR1 P03372 1/20 0.40
KDM4E B2RXH2 2/20 0.39
GRIA2 P42262 1/20 0.39
GRIA4 P48058 1/20 0.39
TSHR P16473 1/20 0.39
CYP1A1 P04798 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP2E1 P05181 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2C8 P10632 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2A6 P11509 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP4B1 P13584 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27214763 0.85 KIF11 (0.62) KIF11ALDH1A1ESR1TSHRCYP1A1
SCHEMBL29152133 0.83 CTSS (0.50) ALDH1A1MAPTSMN1; SMN2TDP1ADORA1
SCHEMBL30662436 0.83 KIF11 (0.50) KIF11ALDH1A1MAPTKDM4EGRIA2
SCHEMBL22978403 0.81 KIF11 (0.71) KIF11ALDH1A1ESR1TSHRCYP1A1
SCHEMBL29152145 0.80 ADORA1 (0.46) ALDH1A1MAPTADORA1KDM4ECYP1A2
SCHEMBL29152127 0.79 ALDH1A1 (0.54) ALDH1A1MAPTADORA1KDM4EMEN1
SCHEMBL29152131 0.79 ADORA1 (0.44) KIF11ALDH1A1MAPTSMN1; SMN2TDP1
SCHEMBL29152134 0.78 AR (0.46) KIF11ALDH1A1MAPTKDM4ETSHR
SCHEMBL780791 0.77 KIF11 (0.52) KIF11ALDH1A1ESR1TSHRCYP1A1
SCHEMBL29152140 0.77 ADORA2A (0.46) ALDH1A1MAPTSMN1; SMN2ADORA1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117164478-A Method for preparing anthracycline derivative 苏州大学 2023-12-05 CN disclosed