SCHEMBL29154384

SCHEMBL29154384

C[Si](C)(C)c1ccc(C(CC(=O)O)(CC(=O)O)C(=O)O)cc1

nearest known ligand 0.43

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
NR1H2 P55055 6/20 0.43
NR1H3 Q13133 6/20 0.43
CYP2C19 P33261 2/20 0.39
HIF1A Q16665 2/20 0.39
MIF P14174 1/20 0.38
SLC13A5 Q86YT5 2/20 0.36
TSHR P16473 2/20 0.36
ALDH1A1 P00352 2/20 0.36
CYP2D6 P10635 1/20 0.33
ACHE P22303 1/20 0.33
HPGD P15428 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.32
ESR1 P03372 1/20 0.32
CYP3A4 P08684 1/20 0.32
ESR2 Q92731 1/20 0.32
MAPT P10636 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29178239 0.79 CES2 (0.47) MIFTSHRALDH1A1
SCHEMBL29154377 0.79 SLC13A5 (0.54) CYP2C19HIF1AMIFSLC13A5TSHR
SCHEMBL12258218 0.79 CYP2C19 (0.42) CYP2C19HIF1AMIFSLC13A5TSHR
SCHEMBL2387498 0.77 HIF1A (0.57) CYP2C19HIF1AMIFSLC13A5TSHR
SCHEMBL2388857 0.76 HIF1A (0.43) CYP2C19HIF1AMIFSLC13A5TSHR
SCHEMBL29154383 0.76 KCNN4 (0.44) CYP2C19HIF1AMIFSLC13A5TSHR
SCHEMBL29154390 0.75 ALDH1A1 (0.46) ALDH1A1SMN1; SMN2MAPT
SCHEMBL29154382 0.75 KIF11 (0.42) CYP2C19HIF1AMIFSLC13A5TSHR
SCHEMBL29178240 0.74 CYP2C9 (0.55) CYP2C19HIF1AMIFSLC13A5TSHR
SCHEMBL29154413 0.72 EPHX2 (0.45) SLC13A5HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117550943-A Based on CO 2 Method for participating in controllable synthesis of polycarboxylic acid compounds 四川大学 2024-02-13 CN disclosed