Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Menthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 known ✓ | Q7Z2W7 | 4/20 | 0.58 |
| ▸ | TRPA1 known ✓ | O75762 | 2/20 | 0.58 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.35 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.34 |
| ▸ | PTGFR | P43088 | 1/20 | 0.34 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Menthol SCHEMBL2052642 | 0.90 | TRPM8 (0.68) | TRPM8TRPA1EPHX1TRPV1CYP19A1 | |
| Levomenthol SCHEMBL2052644 | 0.90 | TRPM8 (0.68) | TRPM8TRPA1EPHX1TRPV1CYP19A1 | |
| Palmitic Acid SCHEMBL28857859 | 0.89 | TRPA1 (0.58) | TRPM8TRPA1GPR84FFAR1FFAR4 | |
| Palmitic Acid SCHEMBL28857858 | 0.89 | TRPA1 (0.58) | TRPM8TRPA1GPR84FFAR1FFAR4 | |
| Levomenthol SCHEMBL29039984 | 0.89 | TRPA1 (0.58) | TRPM8TRPA1GPR84FFAR1FFAR4 | |
| Decanoic Acid SCHEMBL29053352 | 0.89 | TRPA1 (0.58) | TRPM8TRPA1GPR84FFAR1FFAR4 | |
| Menthol SCHEMBL28825012 | 0.89 | TRPA1 (0.58) | TRPM8TRPA1GPR84FFAR1FFAR4 | |
| Dodecanoate SCHEMBL18247782 | 0.89 | TRPA1 (0.58) | TRPM8TRPA1GPR84FFAR1FFAR4 | |
| Stearic Acid SCHEMBL27339395 | 0.89 | TRPA1 (0.58) | TRPM8TRPA1GPR84FFAR1FFAR4 | |
| Myristic Acid SCHEMBL28129926 | 0.89 | TRPA1 (0.58) | TRPM8TRPA1GPR84FFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117582375-A | Antipruritic composition and preparation method and application thereof | 深圳杉海创新技术有限公司 | 2024-02-23 | — | — | CN | claimed |
| CN-117582375-A | Antipruritic composition and preparation method and application thereof | 深圳杉海创新技术有限公司 | 2024-02-23 | — | — | CN | disclosed |
| CN-117582375-A | Antipruritic composition and preparation method and application thereof | 深圳杉海创新技术有限公司 | 2024-02-23 | — | — | CN | disclosed |