Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Menthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 known ✓ | O75762 | 2/20 | 0.58 |
| ▸ | TRPM8 known ✓ | Q7Z2W7 | 2/20 | 0.58 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.47 |
| ▸ | PPARG | P37231 | 7/20 | 0.47 |
| ▸ | PPARD | Q03181 | 7/20 | 0.47 |
| ▸ | PPARA | Q07869 | 7/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TLR2 | O60603 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | FABP4 | P15090 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.47 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dodecanoate SCHEMBL18247782 | 1.00 | TRPA1 (0.58) | TRPA1TRPM8GPR84PPARGPPARD | |
| Oleic Acid SCHEMBL27468982 | 0.93 | PPARG (0.55) | PPARGPPARDPPARATSHRPTPN1 | |
| Stearic Acid SCHEMBL18983186 | 0.85 | TRPA1 (0.54) | TRPA1TRPM8FABP3 | |
| Ricinoleic Acid SCHEMBL9754599 | 0.84 | FFAR1 (0.65) | PPARGPPARDPPARAPTPN1TDP1 | |
| SCHEMBL8660048 | 0.83 | FFAR4 (0.47) | GPR84PPARGPPARDPPARAHDAC11 | |
| Menthol SCHEMBL8607577 | 0.82 | TRPM8 (0.66) | TRPA1TRPM8TSHRALDH1A1KMT2A | |
| Menthol SCHEMBL1664554 | 0.80 | TRPM8 (0.84) | TRPA1TRPM8ALDH1A1 | |
| Menthol SCHEMBL15646159 | 0.79 | TRPM8 (0.70) | TRPA1TRPM8ALDH1A1 | |
| Menthol SCHEMBL20586546 | 0.78 | TRPM8 (0.81) | TRPA1TRPM8ALDH1A1 | |
| Menthol SCHEMBL15914500 | 0.78 | TRPM8 (0.68) | TRPA1TRPM8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118416119-A | Method for extracting triterpene compounds from caulis Sinomenii | 湖南春光九汇现代中药有限公司 | 2024-08-02 | — | — | CN | disclosed |
| CN-117598973-A | Minoxidil eutectic solvent-based pickering emulsion gel and preparation method thereof | 山东理工大学 | 2024-02-27 | — | — | CN | disclosed |
| CN-115449229-B | Modified chitosan/gelatin composite membrane and preparation method and application thereof | 广东省农业科学院蚕业与农产品加工研究所 | 2023-07-18 | — | — | CN | disclosed |
| CN-114805274-B | Green and efficient traditional Chinese medicine glycoside extraction, hydrolysis and aglycone purification method | 湖北工业大学 | 2023-04-25 | — | — | CN | disclosed |
| CN-114805274-A | Green and efficient traditional Chinese medicine glycoside extraction, hydrolysis and aglycone purification method | 湖北工业大学 | 2022-07-29 | — | — | CN | disclosed |