Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Prazosin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 6/20 | 0.94 |
| ▸ | ADRA1B known ✓ | P35368 | 6/20 | 0.94 |
| ▸ | ADRA1D known ✓ | P25100 | 4/20 | 0.94 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.94 |
| ▸ | GLA | P06280 | 4/20 | 0.94 |
| ▸ | GAA | P10253 | 4/20 | 0.94 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.94 |
| ▸ | HPGD | P15428 | 3/20 | 0.94 |
| ▸ | MAPT | P10636 | 3/20 | 0.94 |
| ▸ | RAB9A | P51151 | 3/20 | 0.94 |
| ▸ | LMNA | P02545 | 2/20 | 0.94 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.94 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.94 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.94 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.94 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.94 |
| ▸ | NPC1 | O15118 | 2/20 | 0.94 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.94 |
| ▸ | MEN1 | O00255 | 1/20 | 0.94 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.94 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Prazosin SCHEMBL26524 | 0.97 | ADRA1B (1.00) | ADRA1AADRA1BKDM4EGLAGAA | |
| Prazosin SCHEMBL29376126 | 0.97 | ADRA1B (1.00) | ADRA1AADRA1BKDM4EGLAGAA | |
| Prazosin SCHEMBL41257 | 0.96 | ADRA1B (1.00) | ADRA1AADRA1BKDM4EGLAGAA | |
| Prazosin SCHEMBL611396 | 0.96 | ADRA1B (1.00) | ADRA1AADRA1BKDM4EGLAGAA | |
| Prazosin SCHEMBL1172954 | 0.96 | ADRA1B (1.00) | ADRA1AADRA1BKDM4EGLAGAA | |
| Prazosin SCHEMBL29908896 | 0.96 | ADRA1B (1.00) | ADRA1AADRA1BKDM4EGLAGAA | |
| Prazosin SCHEMBL9663302 | 0.95 | KDM4E (1.00) | ADRA1AADRA1BKDM4EGLAGAA | |
| Prazosin SCHEMBL41258 | 0.95 | ADRA1B (0.96) | ADRA1AADRA1BKDM4EGLAGAA | |
| Prazosin SCHEMBL11656542 | 0.95 | KDM4E (1.00) | ADRA1AADRA1BKDM4EGLAGAA | |
| SCHEMBL7797445 | 0.94 | ADRA1B (0.93) | ADRA1AADRA1BKDM4EGLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117597327-A | Pharmaceutical preparation | 第一波动生物制药股份有限公司 | 2024-02-23 | — | — | CN | disclosed |