Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Prazosin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1B known ✓ | P35368 | 7/20 | 1.00 |
| ▸ | ADRA1A known ✓ | P35348 | 6/20 | 1.00 |
| ▸ | ADRA1D known ✓ | P25100 | 4/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 1.00 |
| ▸ | GLA | P06280 | 4/20 | 1.00 |
| ▸ | GAA | P10253 | 4/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | HPGD | P15428 | 3/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | RAB9A | P51151 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 2/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 2/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 2/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 1.00 |
| ▸ | NPC1 | O15118 | 2/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | SLC22A2 | O15244 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Prazosin SCHEMBL29376126 | 1.00 | ADRA1B (1.00) | ADRA1BADRA1AKDM4EGLAGAA | |
| Prazosin SCHEMBL29908896 | 0.99 | ADRA1B (1.00) | ADRA1BADRA1AKDM4EGLAGAA | |
| Prazosin SCHEMBL611396 | 0.99 | ADRA1B (1.00) | ADRA1BADRA1AKDM4EGLAGAA | |
| Prazosin SCHEMBL41257 | 0.99 | ADRA1B (1.00) | ADRA1BADRA1AKDM4EGLAGAA | |
| Prazosin SCHEMBL1172954 | 0.99 | ADRA1B (1.00) | ADRA1BADRA1AKDM4EGLAGAA | |
| Prazosin SCHEMBL11656542 | 0.98 | KDM4E (1.00) | ADRA1BADRA1AKDM4EGLAGAA | |
| Prazosin SCHEMBL41258 | 0.98 | ADRA1B (0.96) | ADRA1BADRA1AKDM4EGLAGAA | |
| Prazosin SCHEMBL9663302 | 0.98 | KDM4E (1.00) | ADRA1BADRA1AKDM4EGLAGAA | |
| Prazosin SCHEMBL29157754 | 0.97 | ADRA1A (0.94) | ADRA1BADRA1AKDM4EGLAGAA | |
| SCHEMBL7797445 | 0.96 | ADRA1B (0.93) | ADRA1BADRA1AKDM4EGLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 33286 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114514031-B | Laprazole peptide preparation | Jiumit biopharmaceutical Co.,Ltd. (US) | 2026-05-26 | — | — | CN | claimed |
| CN-116850183-B | Methods and pharmaceutical compositions for treating myopia | GRAND PHARMA (CHINA) Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| WO-2026087695-A1 | TREATMENT FOR METABOLIC DISORDER | SAPREME TECHNOLOGIES B.V. (NL) | 2026-04-30 | — | — | WO | claimed |
| WO-2026090251-A1 | METHODS FOR IMPROVING TREATMENT OUTCOMES IN PATIENTS UNDERGOING ULTRAFILTRATION | PROLETARIAT THERAPEUTICS, INC. (US) | 2026-04-30 | — | — | WO | claimed |
| WO-2026087680-A1 | TREATMENT FOR CARDIOVASCULAR DISEASE | SAPREME TECHNOLOGIES B.V. (NL) | 2026-04-30 | — | — | WO | claimed |
| EP-4727545-A2 | COMBINATION TREATMENTS FOR DEPRESSION AND OTHER DISORDERS | Neurawell Therapeutics (US) | 2026-04-22 | — | — | EP | claimed |
| US-12605345-B2 | Transdermal drug delivery system | BioPhysics Pharma, Inc. (US) | 2026-04-21 | — | — | US | claimed |
| EP-4724049-A1 | MODIFIED RELEASE FILL COMPOSITIONS FOR DOSAGE FORMS AND METHODS OF PREPARATION AND USE THEREOF | Catalent Ontario Limited (CA) | 2026-04-15 | — | — | EP | claimed |
| EP-4713433-A2 | LIVER ORGANOIDS WITH INTRAHEPATIC SYMPATHETIC NERVES, AND METHODS OF USE THEREOF | Children's Hospital Medical Center (US) | 2026-03-25 | — | — | EP | claimed |
| US-12564622-B2 | Preventing cytokine release syndrome | THE JOHNS HOPKINS UNIVERSITY (US) | 2026-03-03 | — | — | US | claimed |
| EP-0061186-A1 | Dipeptides containing thialysine and homologs as antihypertensives | MERCK & CO. INC. (US) | 1982-09-29 | — | — | EP | claimed |
| EP-0061187-A1 | Bicyclic lactams as antihypertensives | MERCK & CO. INC. (US) | 1982-09-29 | — | — | EP | claimed |
| EP-0060081-A2 | Piperazinoquinazoline antihypertensives, processes for preparing them, pharmaceutical compositions containing them, and immunogenic protein conjugates formed from them | PFIZER INC. (US) | 1982-09-15 | — | — | EP | claimed |
| EP-0049842-A2 | Substituted enantholactam derivatives, a process for the preparation and a pharmaceutical composition useful in the treatment of hypertension comprising the same, and intermediates | MERCK & CO. INC. (US) | 1982-04-21 | — | — | EP | claimed |
| EP-0049505-A2 | Substituted caprolactam derivatives, a process for preparing and a pharmaceutical composition containing the same, and intermediates | MERCK & CO. INC. (US) | 1982-04-14 | — | — | EP | claimed |
| EP-0046289-A2 | Substituted enantholactam derivatives as antihypertensives, a process for preparing and a pharmaceutical composition containing them, and intermediates | MERCK & CO. INC. (US) | 1982-02-24 | — | — | EP | claimed |
| EP-0046291-A2 | Substituted caprolactam derivatives as antihypertensives, process for preparing them, pharmaceutical composition containing them, and intermediates | MERCK & CO. INC. (US) | 1982-02-24 | — | — | EP | claimed |
| US-4310524-A | TCA Composition and method for rapid onset antidepressant therapy | RICHARDSON-MERRELL, INC. (US) | 1982-01-12 | — | — | US | claimed |
| US-4197301-A | Topical ophthalmic use of Prazosin | ALLERGAN PHARMACEUTICALS, INC. (US) | 1980-04-08 | — | — | US | claimed |
| US-4130647-A | PRAZOSIN OR TRIMAZOSIN OR SALTS | PFIZER INC. (US) | 1978-12-19 | — | — | US | claimed |