Prazosin

Prazosin

SCHEMBL41257

COc1cc2nc(N3CCN(C(=O)c4ccco4)CC3)nc(N)c2cc1OC.Cl

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA1AADRA1BADRA1D

The experimentally established mechanism targets of Prazosin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRA1B known ✓ P35368 7/20 1.00
ADRA1A known ✓ P35348 6/20 1.00
ADRA1D known ✓ P25100 4/20 0.98
KDM4E B2RXH2 5/20 1.00
GLA P06280 4/20 1.00
GAA P10253 4/20 1.00
ALDH1A1 P00352 4/20 1.00
HPGD P15428 3/20 1.00
MAPT P10636 3/20 1.00
SMN1; SMN2 Q16637 3/20 1.00
LMNA P02545 2/20 1.00
CYP3A4 P08684 2/20 1.00
ADRA2B P18089 2/20 1.00
ADRA2C P18825 2/20 1.00
OPRM1 P35372 2/20 1.00
HSD17B10 Q99714 2/20 1.00
GMNN O75496 1/20 1.00
HTR5A P47898 1/20 1.00
BLM P54132 1/20 1.00
PMP22 Q01453 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Prazosin SCHEMBL611396 1.00 ADRA1B (1.00) ADRA1BADRA1AKDM4EGLAGAA
Prazosin SCHEMBL1172954 1.00 ADRA1B (1.00) ADRA1BADRA1AKDM4EGLAGAA
Prazosin SCHEMBL29908896 1.00 ADRA1B (1.00) ADRA1BADRA1AKDM4EGLAGAA
Prazosin SCHEMBL11656542 0.99 KDM4E (1.00) ADRA1BADRA1AKDM4EGLAGAA
Prazosin SCHEMBL9663302 0.99 KDM4E (1.00) ADRA1BADRA1AKDM4EGLAGAA
Prazosin SCHEMBL26524 0.99 ADRA1B (1.00) ADRA1BADRA1AKDM4EGLAGAA
Prazosin SCHEMBL29376126 0.99 ADRA1B (1.00) ADRA1BADRA1AKDM4EGLAGAA
Prazosin SCHEMBL41258 0.97 ADRA1B (0.96) ADRA1BADRA1AKDM4EGLAGAA
Prazosin SCHEMBL29157754 0.96 ADRA1A (0.94) ADRA1BADRA1AKDM4EGLAGAA
SCHEMBL7797445 0.95 ADRA1B (0.93) ADRA1BADRA1AKDM4EGLAGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 8518 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250302887-A1 AMMONIA OXIDIZING MICROORGANISMS FOR THE REGULATION OF BLOOD PRESSURE AOBIOME LLC (US) 2025-10-02 US claimed
WO-2025131019-A1 COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF INHIBIN SUBUNIT BETA E (INHBE) SHANGHAI ARGO BIOPHARMACEUTICAL CO., LTD. (CN) 2025-06-26 WO claimed
US-20250090602-A1 AMMONIA OXIDIZING MICROORGANISMS FOR THE REGULATION OF BLOOD PRESSURE AOBIOME LLC (US) 2025-03-20 US claimed
CN-222618340-U Laboratory is with is a compact press of (2) 佛山慧谷科技股份有限公司 2025-03-14 CN claimed
CN-119234815-A Application of prazosin hydrochloride as strigolactone inhibitor 湖南农业大学 2025-01-03 CN claimed
US-20240299465-A1 AMMONIA OXIDIZING MICROORGANISMS FOR THE REGULATION OF BLOOD PRESSURE AOBIOME LLC (US) 2024-09-12 US claimed
US-20240282425-A1 AUTHENTICATION METHODS AND SYSTEMS FOR DISPENSED PRESCRIPTIONS LOW GORDON KEITH (US) 2024-08-22 US claimed
US-20240252528-A1 Methods Of Treating Metabolic Disorders And Cardiovascular Disease With Inhibin Subunit Beta E (INHBE) Inhibitors REGENERON PHARMACEUTICALS, INC. 2024-08-01 US claimed
CN-221106348-U Mini clamp plate that is duned 江苏新帑健康科技有限公司 2024-06-11 CN claimed
CN-118169271-A Method for detecting alpha-adrenergic receptor blocker, SSRI and 5-ARIs and application thereof 巴中市产品质量检验检测中心 2024-06-11 CN claimed
US-4739055-A HYPOTENSIVE AGENTS ORION-YHTYMA OY (FI) 1988-04-19 US claimed
EP-0222575-A1 Prazosin-pirbuterol combination for bronchodilation PFIZER INC. (US) 1987-05-20 EP claimed
US-4601897-A Prazosin-pirbuterol combination for bronchodilation PFIZER INC. (US) 1986-07-22 US claimed
EP-0126684-A2 Drug delivery system utilizing thermosetting gels MERCK & CO. INC. (US) 1984-11-28 EP claimed
US-4478822-A Drug delivery system utilizing thermosetting gels MERCK & CO., INC. (US) 1984-10-23 US claimed
US-4474752-A DIAMINE MODIFIED POLYOXYETHYLENE-POLYOXYPROPYLENE COPOLYMER MERCK & CO., INC. (US) 1984-10-02 US claimed
US-4472380-A CARBOXYALKYL DIPEPTIDE DERIVATIVES MERCK & CO., INC. (US) 1984-09-18 US claimed
US-4361564-A Renoprotective treatments employing vasodilator compounds EDWARDS K DAVID G 1982-11-30 US claimed
US-4271300-A Method for producing 6,7-dimethoxy-4-amino-2-[4-(2-furoyl)-1-piperazinyl] qu ORION-YHTYMA OY (FI) 1981-06-02 US claimed
US-4092315-A ALPHA-FORM, HYPOTENSIVE AGENT PFIZER INC. (US) 1978-05-30 US claimed