Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.46 |
| ▸ | HRH2 | P25021 | 2/20 | 0.45 |
| ▸ | HRH1 | P35367 | 2/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.42 |
| ▸ | GBA1 | P04062 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrazine SCHEMBL28467340 | 0.81 | TLR8 (0.51) | GPR119HRH2HRH1CNR2TLR8 | |
| SCHEMBL15103054 | 0.79 | KDM4E (0.55) | GPR119TLR8POLBACKR3GBA1 | |
| SCHEMBL106768 | 0.79 | TLR8 (0.54) | HRH2HRH1CNR2TLR8ACKR3 | |
| SCHEMBL8526096 | 0.79 | TLR8 (0.54) | HRH2HRH1CNR2TLR8ACKR3 | |
| SCHEMBL29129466 | 0.78 | TLR8 (0.53) | HRH2HRH1CNR2TLR8ACKR3 | |
| 2-Aminopyridine SCHEMBL28568460 | 0.76 | TLR8 (0.50) | GPR119HRH2HRH1CNR2TLR8 | |
| SCHEMBL4543892 | 0.75 | TLR8 (0.55) | CNR2TLR8ACKR3CHRM2CHRM4 | |
| SCHEMBL28305508 | 0.75 | KDM4E (0.48) | GPR119HRH2HRH1CNR2TLR8 | |
| SCHEMBL17007693 | 0.74 | KDM4E (0.58) | GPR119POLBGBA1LMNADRD2 | |
| SCHEMBL9640623 | 0.72 | HRH2 (0.70) | HRH2HRH1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117642393-A | Novel PARP7 inhibitor and application thereof | 上海齐鲁制药研究中心有限公司 | 2024-03-01 | — | — | CN | disclosed |