Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 2/20 | 0.70 |
| ▸ | HRH1 | P35367 | 2/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | FABP6 | P51161 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18029395 | 0.91 | KDM4E (0.65) | HRH2HRH1KDM4EALDH1A1ALOX15 | |
| SCHEMBL28121975 | 0.85 | FABP6 (0.67) | KDM4EALDH1A1ALOX15FABP6MAPK1 | |
| SCHEMBL31329773 | 0.85 | FABP6 (0.67) | KDM4EALDH1A1ALOX15FABP6MAPK1 | |
| SCHEMBL16980657 | 0.84 | SIGMAR1 (0.72) | HRH2HRH1KDM4EALDH1A1SIGMAR1 | |
| SCHEMBL3323252 | 0.83 | KDM4E (0.65) | KDM4EALDH1A1ALOX15FABP6MAPK1 | |
| SCHEMBL10724043 | 0.82 | SIGMAR1 (0.70) | HRH2HRH1SIGMAR1 | |
| SCHEMBL10723980 | 0.82 | SIGMAR1 (0.70) | HRH2HRH1SIGMAR1 | |
| SCHEMBL10722011 | 0.82 | SIGMAR1 (0.70) | HRH2HRH1SIGMAR1 | |
| SCHEMBL18026640 | 0.82 | ALDH1A1 (0.61) | HRH2HRH1KDM4EALDH1A1ALOX15 | |
| SCHEMBL9763711 | 0.82 | PKM (0.74) | KDM4EALDH1A1FABP6MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0323303-B1 | NICOTINOYL PIPERAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTICAL USE | INSTITUT DE RECHERCHES CHIMIQUES ET BIOLOGIQUES APPLIQUEES (I.R.C.E.B.A.) Société à responsabilité limitée dite: (FR) | 1992-08-12 | — | — | EP | claimed |
| US-4880807-A | ANTIEPILEPTIC AGENTS | INSTITUT DE RECHERCHES CHIMIQUES ET BIOLOGIQUES APPLIQUEES (I.R.C.E.B.A.) (FR) | 1989-11-14 | — | — | US | claimed |
| EP-0323303-A1 | Nicotinoyl piperazine derivatives, process for their preparation and their therapeutical use | INSTITUT DE RECHERCHES CHIMIQUES ET BIOLOGIQUES APPLIQUEES (I.R.C.E.B.A.) Société à responsabilité limitée dite: (FR) | 1989-07-05 | — | — | EP | claimed |
| EP-0323303-B1 | NICOTINOYL PIPERAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTICAL USE | INSTITUT DE RECHERCHES CHIMIQUES ET BIOLOGIQUES APPLIQUEES (I.R.C.E.B.A.) Société à responsabilité limitée dite: (FR) | 1992-08-12 | — | — | EP | disclosed |
| US-4880807-A | ANTIEPILEPTIC AGENTS | INSTITUT DE RECHERCHES CHIMIQUES ET BIOLOGIQUES APPLIQUEES (I.R.C.E.B.A.) (FR) | 1989-11-14 | — | — | US | disclosed |
| US-4880807-A | ANTIEPILEPTIC AGENTS | INSTITUT DE RECHERCHES CHIMIQUES ET BIOLOGIQUES APPLIQUEES (I.R.C.E.B.A.) (FR) | 1989-11-14 | — | — | US | disclosed |
| EP-0323303-A1 | Nicotinoyl piperazine derivatives, process for their preparation and their therapeutical use | INSTITUT DE RECHERCHES CHIMIQUES ET BIOLOGIQUES APPLIQUEES (I.R.C.E.B.A.) Société à responsabilité limitée dite: (FR) | 1989-07-05 | — | — | EP | disclosed |
| EP-0323303-A1 | Nicotinoyl piperazine derivatives, process for their preparation and their therapeutical use | INSTITUT DE RECHERCHES CHIMIQUES ET BIOLOGIQUES APPLIQUEES (I.R.C.E.B.A.) Société à responsabilité limitée dite: (FR) | 1989-07-05 | — | — | EP | disclosed |