Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | KRAS | P01116 | 2/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29168355 | 0.85 | KRAS (0.35) | POLBRAB9AKRASSOS1HPGD | |
| SCHEMBL27186131 | 0.82 | KRAS (0.46) | KRASSOS1 | |
| SCHEMBL27186135 | 0.82 | KRAS (0.46) | KRASSOS1 | |
| SCHEMBL27186168 | 0.71 | NOTUM (0.33) | HPGDALDH1A1 | |
| SCHEMBL29168348 | 0.70 | P2RX7 (0.34) | HPGDALDH1A1KDM4E | |
| SCHEMBL29168410 | 0.69 | KRAS (0.36) | RAB9AKRASSOS1HPGDALDH1A1 | |
| SCHEMBL27186078 | 0.69 | NR4A2 (0.41) | MAPTKMT2AKDM4E | |
| SCHEMBL29168450 | 0.69 | METAP2 (0.34) | RAB9AKRASSOS1NPC1TP53 | |
| SCHEMBL30853329 | 0.69 | BTK (0.37) | HPGDALDH1A1 | |
| SCHEMBL27186280 | 0.67 | KRAS (0.47) | KRASSOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117651701-A | Novel substituted bicyclic aza heterocycles as SOS1 inhibitors | 唯久生物技术(苏州)有限公司 | 2024-03-05 | — | — | CN | disclosed |