Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 2/20 | 0.35 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 14/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.32 |
| ▸ | BRD2 | P25440 | 1/20 | 0.32 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.32 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29168408 | 0.85 | POLB (0.36) | KRASSOS1POLBRAB9AHPGD | |
| SCHEMBL29168348 | 0.82 | P2RX7 (0.34) | P2RX7BRD4ABCB11BRD2BRD3 | |
| SCHEMBL27186284 | 0.81 | KRAS (0.47) | KRASSOS1 | |
| SCHEMBL27186280 | 0.81 | KRAS (0.47) | KRASSOS1 | |
| SCHEMBL27186103 | 0.72 | CECR2 (0.36) | BRD4 | |
| SCHEMBL29168450 | 0.71 | METAP2 (0.34) | KRASSOS1P2RX7RAB9ABRD4 | |
| SCHEMBL27186295 | 0.69 | PIM3 (0.39) | P2RX7BRD4 | |
| SCHEMBL30853318 | 0.69 | BTK (0.39) | BRD4 | |
| SCHEMBL29168383 | 0.67 | KDM4E (0.30) | POLBHPGD | |
| SCHEMBL29168357 | 0.67 | KRAS (0.36) | KRASSOS1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117651701-A | Novel substituted bicyclic aza heterocycles as SOS1 inhibitors | 唯久生物技术(苏州)有限公司 | 2024-03-05 | — | — | CN | disclosed |