Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29661241 | 0.94 | CREBBP (0.35) | GAACREBBPMEN1KMT2ATDP1 | |
| SCHEMBL29687075 | 0.81 | SCN9A (0.35) | KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL22863293 | 0.81 | SCN9A (0.35) | KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL25430094 | 0.71 | DRD2 (0.34) | GAAMEN1KMT2ATDP1MAPT | |
| SCHEMBL16397679 | 0.70 | TDP1 (0.47) | MEN1KMT2ATDP1KDM4EMAPT | |
| SCHEMBL19490017 | 0.70 | HTT (0.34) | GAAKMT2ATDP1MAPTALDH1A1 | |
| SCHEMBL16410266 | 0.69 | ALDH1A1 (0.41) | MEN1KMT2ATDP1MAPTPOLB | |
| SCHEMBL30448079 | 0.69 | MAPT (0.38) | GAACREBBPMEN1KMT2ATDP1 | |
| SCHEMBL21273360 | 0.69 | MAPT (0.38) | GAACREBBPMEN1KMT2ATDP1 | |
| SCHEMBL23536385 | 0.69 | TDP1 (0.43) | CREBBPMEN1KMT2ATDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117700395-A | Substituted tetrahydroisoquinoline derivatives as D1 positive allosteric modulators | UCB生物制药有限责任公司 | 2024-03-15 | — | — | CN | disclosed |
| CN-113993857-B | Substituted tetrahydroisoquinoline derivatives as D1 positive allosteric modulators | UCB生物制药有限责任公司 | 2024-01-02 | — | — | CN | disclosed |
| EP-4267555-A1 | OCTAHYDROISOQUINOLINYL DERIVATIVES | UCB Biopharma SRL (BE) | 2023-11-01 | — | — | EP | disclosed |
| CN-116507332-A | Octahydroisoquinolinyl derivatives | UCB生物制药有限责任公司 | 2023-07-28 | — | — | CN | disclosed |
| WO-2022117678-A1 | OCTAHYDROISOQUINOLINYL DERIVATIVES | UCB Biopharma SRL (BE) | 2022-06-09 | — | — | WO | disclosed |
| EP-3993794-A1 | A SUBSTITUTED TETRAHYDROISOQUINOLINE DERIVATIVE AS A D1 POSITIVE ALLOSTERIC MODULATOR | UCB Biopharma SRL (BE) | 2022-05-11 | — | — | EP | disclosed |
| CN-113993857-A | Substituted tetrahydroisoquinoline derivatives as D1 positive allosteric modulators | UCB生物制药有限责任公司 | 2022-01-28 | — | — | CN | disclosed |