Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 7/20 | 0.33 |
| ▸ | TGFBR2 | P37173 | 5/20 | 0.33 |
| ▸ | ACVR2A | P27037 | 5/20 | 0.33 |
| ▸ | WNT1 | P04628 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 2/20 | 0.32 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.32 |
| ▸ | TTK | P33981 | 1/20 | 0.32 |
| ▸ | CCNK | O75909 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
| ▸ | BUB1 | O43683 | 1/20 | 0.30 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.30 |
| ▸ | MAT2A | P31153 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | BCR | P11274 | 1/20 | 0.30 |
| ▸ | SRC | P12931 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30206243 | 1.00 | TGFBR1 (0.33) | TGFBR1TGFBR2ACVR2AWNT1GSK3B | |
| SCHEMBL30205492 | 0.93 | EML4 (0.33) | TGFBR1TGFBR2ACVR2AWNT1GSK3B | |
| SCHEMBL24943808 | 0.93 | EML4 (0.33) | TGFBR1TGFBR2ACVR2AWNT1GSK3B | |
| SCHEMBL29173658 | 0.91 | BUB1 (0.34) | TGFBR1SYKTTKBUB1PIK3C3 | |
| SCHEMBL30206107 | 0.86 | CYP1A2 (0.35) | TTKCCNA2CDK2SRC | |
| SCHEMBL29173378 | 0.86 | CYP1A2 (0.35) | TTKCCNA2CDK2SRC | |
| SCHEMBL30205968 | 0.85 | HPGD (0.32) | — | |
| SCHEMBL29173474 | 0.85 | HPGD (0.32) | — | |
| SCHEMBL29173448 | 0.82 | SYK (0.36) | SYK | |
| SCHEMBL30206336 | 0.82 | SYK (0.36) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |