Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 10/20 | 0.37 |
| ▸ | CHUK | O15111 | 4/20 | 0.33 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | YTHDC1 | Q96MU7 | 2/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
| ▸ | EIF4EBP1 | Q13541 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30206286 | 0.90 | EIF4EBP1 (0.37) | IKBKBCHUKYTHDC1PDE4APDE4B | |
| SCHEMBL29173737 | 0.80 | IKBKB (0.32) | IKBKBCHUKYTHDC1PDE4APDE4B | |
| SCHEMBL30802785 | 0.80 | IKBKB (0.33) | IKBKBCHUKYTHDC1PDE4APDE4B | |
| SCHEMBL29173707 | 0.80 | IKBKB (0.33) | IKBKBCHUKYTHDC1PDE4APDE4B | |
| SCHEMBL29173564 | 0.79 | IKBKB (0.34) | IKBKBCHUKYTHDC1PDE4APDE4B | |
| SCHEMBL24944752 | 0.79 | EML4 (0.44) | SYK | |
| SCHEMBL30206189 | 0.78 | CCNC (0.36) | — | |
| SCHEMBL24943828 | 0.77 | CDK2 (0.37) | IKBKBCHUKSYK | |
| Formic Acid SCHEMBL30206200 | 0.76 | IKBKB (0.31) | IKBKBCHUKYTHDC1SYK | |
| Formic Acid SCHEMBL30205937 | 0.76 | IKBKB (0.31) | IKBKBCHUKYTHDC1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |