Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | S100A4 | P26447 | 1/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL40537 | 0.84 | NOTUM (0.60) | NOTUMKMT2AALDH1A1TSHRCYP3A4 | |
| SCHEMBL9782150 | 0.73 | NOTUM (1.00) | NOTUMKMT2AALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL30839712 | 0.69 | ALDH1A1 (0.65) | KMT2AALDH1A1TSHRCYP3A4ALOX15 | |
| SCHEMBL27185985 | 0.69 | ALDH1A1 (0.65) | KMT2AALDH1A1TSHRCYP3A4ALOX15 | |
| SCHEMBL30839752 | 0.69 | ALDH1A1 (0.65) | KMT2AALDH1A1TSHRCYP3A4ALOX15 | |
| SCHEMBL19002042 | 0.65 | CYP3A4 (0.40) | KMT2AALDH1A1TSHRCYP3A4ALOX15 | |
| SCHEMBL14906969 | 0.63 | ALDH1A1 (0.56) | KMT2AALDH1A1TSHRCYP3A4ALOX15 | |
| SCHEMBL3328198 | 0.62 | DAO (0.39) | NOTUMKMT2AALDH1A1TSHRCYP3A4 | |
| SCHEMBL2889340 | 0.62 | GRIK1 (0.47) | NOTUMALDH1A1TSHRCYP3A4ALOX15 | |
| SCHEMBL11214035 | 0.62 | TSHR (0.58) | KMT2AALDH1A1TSHRCYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225214-A1 | NOVEL PHENYL-ACETAMIDE AND PHENYL-PROPIONAMIDE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS | NeuroSearch AS (DK) | 2010-09-08 | — | — | EP | disclosed |
| WO-2009068557-A1 | NOVEL PHENYL-ACETAMIDE AND PHENYL-PROPIONAMIDE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2009-06-04 | — | — | WO | disclosed |