Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.60 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.45 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.43 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2917568 | 0.84 | NOTUM (0.57) | NOTUMALDH1A1HPGDKMT2ALMNA | |
| SCHEMBL9782150 | 0.75 | NOTUM (1.00) | NOTUMPDCD1CD274NPSR1ALDH1A1 | |
| SCHEMBL7582370 | 0.70 | AXL (0.46) | CRBNPDCD1CD274ALDH1A1HPGD | |
| SCHEMBL29624840 | 0.66 | AHR (0.64) | ALDH1A1CYP3A4MAPTAHRHSD11B1 | |
| SCHEMBL464507 | 0.66 | AHR (0.64) | ALDH1A1CYP3A4MAPTAHRHSD11B1 | |
| SCHEMBL19872979 | 0.66 | KIF11 (0.40) | CRBNNPSR1ALDH1A1HPGDMEN1 | |
| SCHEMBL11571230 | 0.66 | SMN1; SMN2 (0.47) | CRBNPDCD1CD274ALDH1A1HPGD | |
| SCHEMBL10389746 | 0.65 | HPGD (0.57) | HPGDPOLBMEN1KMT2ALMNA | |
| SCHEMBL17085927 | 0.64 | CRBN (0.40) | CRBNPDCD1CD274NPSR1ALDH1A1 | |
| SCHEMBL181974 | 0.63 | NOTUM (0.67) | NOTUMPDCD1CD274ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120100989-A1 | 3-Aryl-4-(2-thienylmethylene)isoxazol-5(4H)-ones as Fungicides | BAYER CROPSCIENCE AG (DE) | 2012-04-26 | — | — | US | disclosed |
| WO-2011161035-A1 | 3-ARYL-4-(2-THIENYLMETHYLENE)-ISOXAZOL-5(4H)-ONES AS FUNGICIDES | BAYER CROPSCIENCE AG (DE) | 2011-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120100989-A1 | 3-Aryl-4-(2-thienylmethylene)isoxazol-5(4H)-ones as Fungicides | CYP4X1, CYP4Z1, TH | NOTUM 1620/4885CRBN 149/4885PDCD1 1223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.