SCHEMBL29183995

SCHEMBL29183995

COC(=O)CCCCN1CCN(c2nc(-c3ccccc3N)nc(N3CCOCC3)n2)CC1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 4/20 0.43
DRD3 P35462 2/20 0.43
PIK3CA P42336 14/20 0.43
MTOR P42345 4/20 0.43
ADRA1A P35348 1/20 0.42
HDAC3 O15379 7/20 0.41
HDAC1 Q13547 5/20 0.41
HDAC2 Q92769 5/20 0.41
PIK3R1 P27986 1/20 0.41
GLA P06280 2/20 0.41
KMT2A Q03164 2/20 0.41
KDM4E B2RXH2 1/20 0.41
MEN1 O00255 1/20 0.41
ALDH1A1 P00352 1/20 0.41
GAA P10253 1/20 0.41
HPGD P15428 1/20 0.41
HTR1A P08908 2/20 0.41
HTR7 P34969 2/20 0.41
HTR6 P50406 2/20 0.41
PIK3CG P48736 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29183994 0.86 PIK3CA (0.58) DRD2DRD3PIK3CAMTORHDAC3
SCHEMBL29183975 0.85 PIK3CA (0.58) PIK3CAMTORHDAC3HDAC1HDAC2
SCHEMBL29183992 0.84 PIK3CA (0.57) PIK3CAMTORHDAC3HDAC1HDAC2
SCHEMBL29183799 0.83 PIK3CA (0.61) PIK3CAMTORHDAC3HDAC1HDAC2
SCHEMBL29183819 0.82 PIK3CA (0.60) PIK3CAMTORHDAC3HDAC1HDAC2
SCHEMBL29184046 0.81 PIK3CA (0.64) PIK3CAMTORPIK3R1PIK3CGPIK3CD
SCHEMBL29183989 0.80 PIK3CA (0.65) PIK3CAMTORPIK3R1PIK3CGPIK3CD
SCHEMBL29183797 0.77 MTOR (0.65) PIK3CAMTORPIK3R1PIK3CGPIK3CD
SCHEMBL29183979 0.73 HDAC1 (0.60) PIK3CAMTORHDAC3HDAC1HDAC2
SCHEMBL1085753 0.72 HTR1A (0.65) DRD2DRD3HTR1AHTR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117777042-A Triazine hydroxamic acid derivative and preparation method and application thereof 长沙医学院 2024-03-29 CN disclosed