Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 5/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | LSS | P48449 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24840031 | 1.00 | SIGMAR1 (0.40) | SIGMAR1MEN1GFERKMT2APOLB | |
| SCHEMBL31359742 | 1.00 | SIGMAR1 (0.40) | SIGMAR1MEN1GFERKMT2APOLB | |
| SCHEMBL26115121 | 0.84 | KMT2A (0.50) | SIGMAR1MEN1KMT2APOLBTSHR | |
| SCHEMBL29189098 | 0.82 | JAK1 (0.42) | MEN1GFERKMT2AGSK3BJAK2 | |
| SCHEMBL29189096 | 0.82 | JAK1 (0.42) | MEN1GFERKMT2AGSK3BJAK2 | |
| SCHEMBL30718319 | 0.81 | JAK1 (0.40) | SIGMAR1JAK2JAK3 | |
| SCHEMBL30718299 | 0.81 | JAK1 (0.40) | SIGMAR1JAK2JAK3 | |
| SCHEMBL26115853 | 0.78 | NPSR1 (0.50) | MEN1KMT2ATSHRMAPK1SMN1; SMN2 | |
| SCHEMBL30168043 | 0.78 | PRMT5 (0.46) | MEN1KMT2APOLBJAK2HTR6 | |
| SCHEMBL24840030 | 0.78 | PRMT5 (0.46) | MEN1KMT2APOLBJAK2HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240327413-A1 | NLRP3 MODULATORS | ZOMAGEN BIOSCIENCES LTD | 2024-10-03 | — | — | US | disclosed |
| EP-4362946-A1 | NLRP3 MODULATORS | Zomagen Biosciences Ltd (US) | 2024-05-08 | — | — | EP | disclosed |
| CN-117881401-A | NLRP3 modulators | 祖玛珍生物科学有限公司 | 2024-04-12 | — | — | CN | disclosed |
| WO-2023278438-A1 | NLRP3 MODULATORS | ZOMAGEN BIOSCIENCES LTD (US) | 2023-01-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240327413-A1 | NLRP3 MODULATORS | NLRP3, NLRP1, NOD1 | SIGMAR1 1923/4885MEN1 4787/4885GFER 3729/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.