Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA5A | P35218 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2920999 | 0.91 | BRD4 (0.36) | BRD4CREBBPALDH1A1L3MBTL1OPRM1 | |
| SCHEMBL2925075 | 0.88 | TSHR (0.41) | ALDH1A1OPRM1SIGMAR1GAAKMT2A | |
| SCHEMBL2924986 | 0.83 | CCNA2 (0.49) | BRD4CREBBPALDH1A1L3MBTL1OPRM1 | |
| SCHEMBL2915619 | 0.82 | CCNA2 (0.50) | BRD4CREBBPCCNA2CDK2CCNA1 | |
| SCHEMBL2922865 | 0.80 | OPRM1 (0.47) | OPRM1SIGMAR1 | |
| SCHEMBL2923596 | 0.80 | CCNA2 (0.42) | BRD4CREBBPKMT2ACCNA2CDK2 | |
| SCHEMBL2924963 | 0.79 | OPRM1 (0.47) | OPRM1SIGMAR1 | |
| SCHEMBL2923956 | 0.78 | CCNA2 (0.54) | BRD4CREBBPCCNA2CDK2CCNA1 | |
| SCHEMBL2924758 | 0.76 | KDM4E (0.45) | BRD4CREBBPALDH1A1OPRM1MEN1 | |
| SCHEMBL2916852 | 0.69 | CCNA2 (0.49) | BRD4CREBBPALDH1A1L3MBTL1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1320531-B1 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PFIZER ITALIA SRL (IT) | 2010-09-08 | — | — | EP | claimed |