Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 16/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 14/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | BRS3 | P32247 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2924963 | 0.89 | OPRM1 (0.47) | OPRM1SIGMAR1KCNH2DRD4 | |
| SCHEMBL2915619 | 0.82 | CCNA2 (0.50) | — | |
| SCHEMBL2924986 | 0.81 | CCNA2 (0.49) | OPRM1SIGMAR1 | |
| SCHEMBL2925075 | 0.81 | TSHR (0.41) | OPRM1SIGMAR1 | |
| SCHEMBL2924758 | 0.81 | KDM4E (0.45) | OPRM1 | |
| SCHEMBL2919774 | 0.80 | BRD4 (0.36) | OPRM1SIGMAR1 | |
| SCHEMBL2920999 | 0.80 | BRD4 (0.36) | OPRM1SIGMAR1 | |
| SCHEMBL2923596 | 0.80 | CCNA2 (0.42) | — | |
| SCHEMBL2923956 | 0.78 | CCNA2 (0.54) | — | |
| SCHEMBL4944611 | 0.74 | KDM4E (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1320531-B1 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PFIZER ITALIA SRL (IT) | 2010-09-08 | — | — | EP | claimed |