Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2919774 | 0.88 | BRD4 (0.36) | GAAKMT2AALDH1A1OPRM1SIGMAR1 | |
| SCHEMBL2920999 | 0.88 | BRD4 (0.36) | TSHRGAAKMT2AALDH1A1KDM4E | |
| SCHEMBL2922865 | 0.81 | OPRM1 (0.47) | OPRM1SIGMAR1 | |
| SCHEMBL2924963 | 0.80 | OPRM1 (0.47) | OPRM1SIGMAR1 | |
| SCHEMBL2915619 | 0.79 | CCNA2 (0.50) | MAPTLMNA | |
| SCHEMBL2924986 | 0.78 | CCNA2 (0.49) | ALDH1A1OPRM1SIGMAR1 | |
| SCHEMBL2924758 | 0.77 | KDM4E (0.45) | CYP2C19KMT2AALDH1A1NPSR1KDM4E | |
| SCHEMBL2923596 | 0.76 | CCNA2 (0.42) | KMT2A | |
| SCHEMBL2923956 | 0.75 | CCNA2 (0.54) | MAPT | |
| SCHEMBL2920857 | 0.74 | CCNA2 (0.54) | TSHRGAACYP2C19KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1320531-B1 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PFIZER ITALIA SRL (IT) | 2010-09-08 | — | — | EP | claimed |