Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | MPO | P05164 | 3/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2922743 | 0.88 | — | — | |
| SCHEMBL2923312 | 0.86 | SLC6A2 (0.45) | PPARGPPARASLC6A2SLC6A4SLC6A3 | |
| 3-(4-Hydroxy-Phenethyl)-5-Phenethyl-4,5-Dihydro-Isoxazole (Enantiomeric Mix) SCHEMBL2923098 | 0.84 | DRD2 (0.47) | PPARGPPARASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2914076 | 0.81 | KEAP1 (0.42) | — | |
| 3-(3-Hydroxy-Phenethyl)-5-Phenethyl-4,5-Dihydro-Isoxazole (Enantiomeric Mix) SCHEMBL2912741 | 0.81 | OPRK1 (0.45) | PPARGPPARA | |
| SCHEMBL2920823 | 0.79 | SLC6A2 (0.44) | PPARGPPARASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2922805 | 0.79 | MPO (0.44) | MPO | |
| SCHEMBL28145201 | 0.77 | SLC6A2 (0.43) | PPARGPPARASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2916369 | 0.73 | — | — | |
| SCHEMBL2913753 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100267784-A1 | NOVEL 4,5-DIHYDROISOXAZOLES WITH ESTROGENIC ACTIVITY | PULKKINEN JUHA | 2010-10-21 | — | — | US | disclosed |
| US-20100267784-A1 | NOVEL 4,5-DIHYDROISOXAZOLES WITH ESTROGENIC ACTIVITY | PULKKINEN JUHA | 2010-10-21 | — | — | US | disclosed |
| US-20100267784-A1 | NOVEL 4,5-DIHYDROISOXAZOLES WITH ESTROGENIC ACTIVITY | PULKKINEN JUHA | 2010-10-21 | — | — | US | disclosed |
| EP-2222653-A1 | NOVEL 4,5-DIHYDROISOXAZOLES WITH ESTROGENIC ACTIVITY | Pulkkinen, Juha (FI) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009066009-A1 | NOVEL 4,5-DIHYDROISOXAZOLES WITH ESTROGENIC ACTIVITY | PULKKINEN JUHA (FI) | 2009-05-28 | — | — | WO | disclosed |
| WO-2009066009-A1 | NOVEL 4,5-DIHYDROISOXAZOLES WITH ESTROGENIC ACTIVITY | PULKKINEN JUHA (FI) | 2009-05-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267784-A1 | NOVEL 4,5-DIHYDROISOXAZOLES WITH ESTROGENIC ACTIVITY | ESR2, GPER1, CYP19A1 | DRD1 2312/4885PPARG 140/4885PPARA 290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.