SCHEMBL29200437

SCHEMBL29200437

NNC(=O)c1cccc(F)c1.[N-]=[N+]=NC(=O)c1cccc(F)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 1/20 0.50
HDAC6 Q9UBN7 1/20 0.50
ALDH1A1 P00352 3/20 0.46
KDM4E B2RXH2 3/20 0.46
PARP1 P09874 1/20 0.45
MEN1 O00255 4/20 0.44
KMT2A Q03164 4/20 0.44
AOC2 O75106 1/20 0.44
CES2 O00748 1/20 0.44
CES1 P23141 1/20 0.44
KCNK3 O14649 2/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
HPGD P15428 1/20 0.42
NPC1 O15118 3/20 0.42
RAB9A P51151 3/20 0.42
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2C19 P33261 1/20 0.41
GAA P10253 1/20 0.41
CASP3 P42574 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29200432 0.88 CES2 (0.55) HDAC1HDAC6ALDH1A1KDM4EPARP1
SCHEMBL405785 0.83 HDAC1 (0.69) HDAC1HDAC6ALDH1A1KDM4EPARP1
SCHEMBL30046370 0.83 HDAC1 (0.69) HDAC1HDAC6ALDH1A1KDM4EPARP1
SCHEMBL28396264 0.77 L3MBTL1 (0.41) HDAC6PARP1MEN1KMT2ACES2
SCHEMBL28924563 0.74 PBRM1 (0.52) ALDH1A1KDM4EMEN1KMT2ANPC1
SCHEMBL4238810 0.72 KMT2A (0.67) ALDH1A1KDM4EMEN1KMT2AKCNK3
SCHEMBL28413031 0.72 CES2 (0.46) HDAC1HDAC6ALDH1A1PARP1MEN1
SCHEMBL77384 0.71 ALDH1A1 (0.76) HDAC6ALDH1A1KDM4EMEN1KMT2A
SCHEMBL16588079 0.70 ALDH1A1 (0.50) HDAC1HDAC6ALDH1A1KDM4EMEN1
SCHEMBL19398201 0.69 PARP1 (0.52) HDAC6PARP1MEN1KMT2AKCNK3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117658868-A Benzamide derivative and preparation method and application thereof 中山大学 2024-03-08 CN disclosed