SCHEMBL29208258

SCHEMBL29208258

CCOC(=O)C(CC(=C(F)F)c1ccc2ccccc2c1)Nc1ccccc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 1/20 0.40
P2RY12 Q9H244 1/20 0.40
CA12 O43570 3/20 0.39
CA1 P00915 3/20 0.39
CA2 P00918 3/20 0.39
CA9 Q16790 3/20 0.39
NPC1 O15118 4/20 0.39
RAB9A P51151 3/20 0.39
MEN1 O00255 3/20 0.39
KMT2A Q03164 3/20 0.39
DHODH Q02127 1/20 0.38
ADRB2 P07550 1/20 0.38
ADRB1 P08588 1/20 0.38
ADRB3 P13945 1/20 0.38
CNR2 P34972 1/20 0.38
HDAC3 O15379 1/20 0.38
HDAC1 Q13547 1/20 0.38
HDAC2 Q92769 1/20 0.38
MAPT P10636 1/20 0.37
ALDH1A1 P00352 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29208309 0.86 CYP26A1 (0.43) CA12CA1CA2CA9NPC1
SCHEMBL29208268 0.81 MAOB (0.49) RAB9AMEN1KMT2A
SCHEMBL29208274 0.79 CYP19A1 (0.42) CA12CA1CA2CA9RAB9A
SCHEMBL29208272 0.75 CYP26A1 (0.45) NPC1RAB9AMEN1KMT2AMAPT
SCHEMBL11364004 0.75 GAA (0.50) TACR1NPC1RAB9AMEN1KMT2A
SCHEMBL29208257 0.74 MGLL (0.45) TACR1NPC1RAB9AMEN1KMT2A
SCHEMBL4424175 0.73 DHODH (0.48) TACR1NPC1RAB9AMEN1KMT2A
SCHEMBL28975793 0.71 PIN1 (0.48) RAB9AMEN1KMT2AHDAC3HDAC1
SCHEMBL27481741 0.71 GAA (0.50) CA12CA1CA2CA9NPC1
SCHEMBL2948701 0.71 TACR1 (0.51) TACR1P2RY12NPC1RAB9AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117964504-A Preparation method of gem-difluoroallylglycine or polypeptide derivative 南京林业大学 2024-05-03 CN disclosed