Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.44 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.43 |
| ▸ | MGAM | O43451 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | SI | P14410 | 3/20 | 0.43 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25275491 | 0.84 | KMT2A (0.63) | TACR1SMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL2947306 | 0.84 | HDAC1 (0.52) | SMN1; SMN2NPC1RAB9AKMT2AHDAC1 | |
| SCHEMBL13235318 | 0.81 | ALDH1A1 (0.51) | NPC1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL5106153 | 0.80 | NPC1 (0.51) | SMN1; SMN2KDM4EHPGDNPC1RAB9A | |
| SCHEMBL656638 | 0.76 | PDPK1 (0.53) | SMN1; SMN2KDM4EHPGDNPC1RAB9A | |
| SCHEMBL29362884 | 0.76 | ALDH1A1 (0.55) | SMN1; SMN2KDM4EHPGDNPC1RAB9A | |
| SCHEMBL853199 | 0.76 | ALDH1A1 (0.55) | SMN1; SMN2KDM4EHPGDNPC1RAB9A | |
| SCHEMBL657387 | 0.75 | PDPK1 (0.58) | SMN1; SMN2KDM4EHPGDNPC1RAB9A | |
| SCHEMBL14577821 | 0.73 | ADRB2 (0.52) | SMN1; SMN2KDM4EHPGDNPC1RAB9A | |
| SCHEMBL18397603 | 0.73 | PIN1 (0.52) | NPC1RAB9AMEN1KMT2AP2RY12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1707559-B1 | METHOD OF ENANTIOSELECTIVE NUCLEOPHILIC ADDITION REACTION OF AN ENAMIDE TO AN IMINE AND METHOD OF SYNTHESIZING ALPHA-AMINO-GAMMA-KETO ACID ESTER | JAPAN SCIENCE & TECH AGENCY (JP) | 2012-06-13 | — | — | EP | disclosed |
| US-7754898-B2 | Method of enantioselective nucleophilic addition reaction of enamide to imine and synthesis method of α-amino-γ-keto acid ester | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2010-07-13 | — | — | US | disclosed |
| US-7754898-B2 | Method of enantioselective nucleophilic addition reaction of enamide to imine and synthesis method of α-amino-γ-keto acid ester | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2010-07-13 | — | — | US | disclosed |
| US-7754898-B2 | Method of enantioselective nucleophilic addition reaction of enamide to imine and synthesis method of α-amino-γ-keto acid ester | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2010-07-13 | — | — | US | disclosed |
| US-20070161804-A1 | Method of enantioselective nucleophilic addition reaction of enamide to imine and synthesis method of a-amino-y-keto acid ester | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2007-07-12 | — | — | US | disclosed |
| US-20070161804-A1 | Method of enantioselective nucleophilic addition reaction of enamide to imine and synthesis method of a-amino-y-keto acid ester | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2007-07-12 | — | — | US | disclosed |
| US-20070161804-A1 | Method of enantioselective nucleophilic addition reaction of enamide to imine and synthesis method of a-amino-y-keto acid ester | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2007-07-12 | — | — | US | disclosed |
| EP-1707559-A1 | METHOD OF ENANTHIO-SELECTIVE NUCLEOPHILIC ADDITION REACTION FOR CONVERSION OF ENAMIDE TO IMINE AND METHOD OF SYNTHESIZING ALPHA AMINO-GAMMA-KETO ACID ESTER | Japan Science and Technology Agency (JP) | 2006-10-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161804-A1 | Method of enantioselective nucleophilic addition reaction of enamide to imine and synthesis method of a-amino-y-keto acid ester | NAAA, ENY2, ASNS | TACR1 3929/4885SMN1; SMN2 3315/4885KDM4E 2002/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.