Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 3/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25427528 | 0.89 | MTNR1A (0.37) | MTNR1AMTNR1BMAPTHDAC8MCL1 | |
| SCHEMBL29208414 | 0.88 | CCNC (0.38) | PLK1CYP3A4MTNR1AMTNR1BKDM4E | |
| SCHEMBL29208443 | 0.85 | CA1 (0.37) | PLK1CA1CA2DDB1CRBN | |
| SCHEMBL29208438 | 0.78 | LOXL2 (0.38) | DDB1CRBNTLR7HDAC8 | |
| SCHEMBL24414562 | 0.77 | MTNR1A (0.42) | CA1CA2MTNR1AMTNR1BHDAC8 | |
| SCHEMBL30991815 | 0.77 | MTNR1A (0.42) | CA1CA2MTNR1AMTNR1BHDAC8 | |
| SCHEMBL25423878 | 0.76 | KDM4E (0.41) | MTNR1AMTNR1BKDM4EMAPTHDAC8 | |
| SCHEMBL29208419 | 0.76 | KDM4E (0.38) | MTNR1AMTNR1BKDM4EMAPTHDAC8 | |
| SCHEMBL29208497 | 0.74 | SUCNR1 (0.35) | CA1CA2DDB1CRBNHDAC8 | |
| SCHEMBL25426273 | 0.74 | MTNR1A (0.34) | MTNR1AMTNR1BMAPTHDAC8MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116391129-A | Target binding assays for RAS proteins | 普罗美加公司 | 2023-07-04 | — | — | CN | disclosed |
| WO-2022047186-A1 | TARGET ENGAGEMENT ASSAY FOR RAS PROTEINS | PROMEGA CORPORATION (US) | 2022-03-03 | — | — | WO | disclosed |
| US-20220064696-A1 | TARGET ENGAGEMENT ASSAY FOR RAS PROTEINS | PROMEGA CORPORATION (US) | 2022-03-03 | — | — | US | disclosed |