Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.37 |
| ▸ | CA2 | P00918 | 3/20 | 0.37 |
| ▸ | PLK1 | P53350 | 3/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.33 |
| ▸ | IL6 | P05231 | 2/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25426273 | 0.90 | MTNR1A (0.34) | MTNR1AMTNR1B | |
| SCHEMBL29208507 | 0.89 | NAMPT (0.37) | CA1CA2CYP3A4 | |
| SCHEMBL29208415 | 0.88 | CCNC (0.36) | CA1CA2PLK1HRH3CYP3A4 | |
| SCHEMBL29208453 | 0.85 | PLK1 (0.38) | CA1CA2PLK1HRH3DDB1 | |
| SCHEMBL29208438 | 0.78 | LOXL2 (0.38) | DDB1CRBNTLR7IL6ADORA1 | |
| SCHEMBL25424948 | 0.77 | ALDH1A1 (0.40) | MTNR1AMTNR1B | |
| SCHEMBL29208420 | 0.77 | ALDH1A1 (0.37) | MTNR1AMTNR1B | |
| SCHEMBL25426067 | 0.76 | CPB2 (0.36) | MTNR1AMTNR1B | |
| SCHEMBL29208368 | 0.76 | CCNC (0.42) | CA1CA2 | |
| SCHEMBL29208505 | 0.75 | EP300 (0.42) | CA1CA2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116391129-A | Target binding assays for RAS proteins | 普罗美加公司 | 2023-07-04 | — | — | CN | disclosed |
| WO-2022047186-A1 | TARGET ENGAGEMENT ASSAY FOR RAS PROTEINS | PROMEGA CORPORATION (US) | 2022-03-03 | — | — | WO | disclosed |
| US-20220064696-A1 | TARGET ENGAGEMENT ASSAY FOR RAS PROTEINS | PROMEGA CORPORATION (US) | 2022-03-03 | — | — | US | disclosed |