Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 4/20 | 0.37 |
| ▸ | CA1 | P00915 | 6/20 | 0.36 |
| ▸ | CA2 | P00918 | 6/20 | 0.36 |
| ▸ | CA12 | O43570 | 4/20 | 0.36 |
| ▸ | CA9 | Q16790 | 4/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | STING1 | Q86WV6 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29208443 | 0.89 | CA1 (0.37) | CA1CA2CYP3A4 | |
| SCHEMBL25426067 | 0.87 | CPB2 (0.36) | NAMPTHDAC8CPB2 | |
| SCHEMBL29208368 | 0.86 | CCNC (0.42) | NAMPTCA1CA2CA12CA9 | |
| SCHEMBL29208505 | 0.85 | EP300 (0.42) | CA1CA2CA12CA9DYRK1A | |
| SCHEMBL30991815 | 0.84 | MTNR1A (0.42) | CA1CA2DRD2HDAC8 | |
| SCHEMBL24414562 | 0.84 | MTNR1A (0.42) | CA1CA2DRD2HDAC8 | |
| SCHEMBL29208495 | 0.79 | ADA (0.35) | HDAC8CPB2 | |
| SCHEMBL21071078 | 0.79 | CA1 (0.46) | CA1CA2CA12CA9DYRK1A | |
| SCHEMBL29208400 | 0.77 | HDAC8 (0.47) | NAMPTCA1CA2HDAC8BRD4 | |
| SCHEMBL25426273 | 0.77 | MTNR1A (0.34) | HDAC8CPB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116391129-A | Target binding assays for RAS proteins | 普罗美加公司 | 2023-07-04 | — | — | CN | disclosed |
| WO-2022047186-A1 | TARGET ENGAGEMENT ASSAY FOR RAS PROTEINS | PROMEGA CORPORATION (US) | 2022-03-03 | — | — | WO | disclosed |
| US-20220064696-A1 | TARGET ENGAGEMENT ASSAY FOR RAS PROTEINS | PROMEGA CORPORATION (US) | 2022-03-03 | — | — | US | disclosed |