Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.42 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.42 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29208492 | 0.92 | BRD9 (0.44) | HDAC8HDAC6HDAC10HDAC1HDAC11 | |
| SCHEMBL29588065 | 0.92 | BRD9 (0.44) | HDAC8HDAC6HDAC10HDAC1HDAC11 | |
| SCHEMBL29208475 | 0.84 | ALDH1A1 (0.56) | HDAC8HDAC6HDAC10HDAC1HDAC11 | |
| SCHEMBL25425543 | 0.83 | TSHR (0.49) | HDAC8HDAC6HDAC10HDAC1HDAC11 | |
| SCHEMBL24414562 | 0.83 | MTNR1A (0.42) | HDAC8HDAC6HDAC1CA1CA2 | |
| SCHEMBL30991815 | 0.83 | MTNR1A (0.42) | HDAC8HDAC6HDAC1CA1CA2 | |
| SCHEMBL24414622 | 0.82 | BRD9 (0.46) | HDAC8HDAC6HDAC10HDAC1BRD9 | |
| SCHEMBL99337 | 0.78 | TPSAB1 (0.56) | HDAC1PRSS1NAMPTGAAL3MBTL1 | |
| SCHEMBL29208505 | 0.77 | EP300 (0.42) | HDAC8HDAC6HDAC10HDAC1HDAC11 | |
| SCHEMBL29208507 | 0.77 | NAMPT (0.37) | HDAC8NAMPTCA1CA2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116391129-A | Target binding assays for RAS proteins | 普罗美加公司 | 2023-07-04 | — | — | CN | disclosed |
| WO-2022047186-A1 | TARGET ENGAGEMENT ASSAY FOR RAS PROTEINS | PROMEGA CORPORATION (US) | 2022-03-03 | — | — | WO | disclosed |
| US-20220064696-A1 | TARGET ENGAGEMENT ASSAY FOR RAS PROTEINS | PROMEGA CORPORATION (US) | 2022-03-03 | — | — | US | disclosed |