Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 13/20 | 0.80 |
| ▸ | OPRL1 | P41146 | 11/20 | 0.80 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.68 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.68 |
| ▸ | HTR1A | P08908 | 5/20 | 0.68 |
| ▸ | DRD2 | P14416 | 5/20 | 0.68 |
| ▸ | DRD4 | P21917 | 5/20 | 0.68 |
| ▸ | HRH2 | P25021 | 5/20 | 0.68 |
| ▸ | HTR1D | P28221 | 5/20 | 0.68 |
| ▸ | HTR2A | P28223 | 5/20 | 0.68 |
| ▸ | HTR2C | P28335 | 5/20 | 0.68 |
| ▸ | HTR7 | P34969 | 5/20 | 0.68 |
| ▸ | DRD1 | P21728 | 4/20 | 0.68 |
| ▸ | DRD5 | P21918 | 4/20 | 0.68 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.68 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.68 |
| ▸ | DRD3 | P35462 | 4/20 | 0.68 |
| ▸ | HTR2B | P41595 | 4/20 | 0.68 |
| ▸ | HTR6 | P50406 | 4/20 | 0.68 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11450342 | 0.86 | OPRM1 (0.61) | OPRM1OPRL1OPRD1OPRK1HTR1A | |
| Hydrochloric Acid SCHEMBL11437813 | 0.85 | OPRM1 (0.60) | OPRM1OPRL1OPRD1OPRK1HTR1A | |
| SCHEMBL13543993 | 0.84 | CCR3 (0.72) | OPRM1OPRL1DRD2DRD4DRD3 | |
| SCHEMBL3859039 | 0.84 | OPRM1 (0.70) | OPRM1OPRL1OPRD1OPRK1HTR1A | |
| SCHEMBL14282239 | 0.84 | OPRM1 (0.76) | OPRM1OPRL1OPRD1OPRK1HTR1A | |
| SCHEMBL4710045 | 0.82 | OPRM1 (0.72) | OPRM1OPRL1OPRD1OPRK1HTR1A | |
| SCHEMBL3850816 | 0.81 | OPRM1 (0.69) | OPRM1OPRL1OPRD1OPRK1HTR1A | |
| SCHEMBL14282238 | 0.81 | OPRM1 (0.67) | OPRM1OPRL1OPRD1OPRK1HTR1A | |
| SCHEMBL905028 | 0.81 | OPRM1 (1.00) | OPRM1OPRL1OPRD1OPRK1HTR1A | |
| SCHEMBL4778246 | 0.81 | OPRL1 (0.78) | OPRM1OPRL1OPRD1OPRK1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE41315-E1 | Modulators of dopamine neurotransmission | NSAB, FILIAL AF NEUROSEARCH SWEDEN AB (DE) | 2010-05-04 | — | — | US | disclosed |
| CN-100448875-C | Substituted 1-piperazinoylpiperidine derivatives, their preparation and therapeutic use | SANOFI AVENTIS (FR) | 2009-01-07 | — | — | CN | disclosed |
| US-7468368-B2 | Piperazinylacylpiperidine derivatives, their preparation and therapeutic use thereof | SANOFI AVENTIS (FR) | 2008-12-23 | — | — | US | disclosed |
| EP-1419773-B1 | 4-Phenylpiperidine derivatives as modulators of dopamine neurotransmission | NEUROSEARCH SWEDEN AB (SE) | 2008-06-04 | — | — | EP | disclosed |
| US-7294628-B2 | Piperazinylacylpiperidine derivatives, their preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2007-11-13 | — | — | US | disclosed |
| EP-1513835-B1 | PIPERAZINYLACYLPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2006-08-16 | — | — | EP | disclosed |
| US-20060167007-A1 | Piperazinylacylpiperidine derivatives, their preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2006-07-27 | — | — | US | disclosed |
| EP-1513836-B1 | PIPERAZINYLACYLPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2006-05-03 | — | — | EP | disclosed |
| CN-1675203-A | Substituted 1-piperazinoylpiperidine derivatives, their preparation and therapeutic use | SANOFI AVENTIS (FR) | 2005-09-28 | — | — | CN | disclosed |
| US-20050176722-A1 | Piperazinylacylpiperidine derivatives, their preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2005-08-11 | — | — | US | disclosed |
| US-6924374-B2 | Central nervous system disorders; psychological disorders | A. CARLSSON RESEARCH AB (SE) | 2005-08-02 | — | — | US | disclosed |
| EP-1513835-A1 | PIPERAZINYLACYLPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2005-03-16 | — | — | EP | disclosed |
| EP-1513836-A1 | PIPERAZINYLACYLPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2005-03-16 | — | — | EP | disclosed |
| EP-1419773-A2 | 4-Phenylpiperidine derivatives as modulators of dopamine neurotransmission | A. Carlsson Research AB (SE) | 2004-05-19 | — | — | EP | disclosed |
| WO-2003104225-A1 | PIPERAZINYLACYLPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-SYNTHELABO (FR) | 2003-12-18 | — | — | WO | disclosed |
| WO-2003104226-A1 | PIPERAZINYLACYLPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-SYNTHELABO (FR) | 2003-12-18 | — | — | WO | disclosed |
| US-20030004169-A1 | Modulators of dopamine neurotransmission | NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE (DK) | 2003-01-02 | — | — | US | disclosed |
| EP-1240143-A1 | NEW MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. Carlsson Research AB (SE) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001046146-A1 | NEW MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2001-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060167007-A1 | Piperazinylacylpiperidine derivatives, their preparation and therapeutic use thereof | NR5A2, NR3C2, NR3C1 | OPRM1 104/4885OPRL1 29/4885OPRD1 71/4885 |
| US-20050176722-A1 | Piperazinylacylpiperidine derivatives, their preparation and therapeutic use thereof | NR5A2, NR3C1, CBR1 | OPRM1 52/4885OPRL1 24/4885OPRD1 47/4885 |
| US-20030004169-A1 | Modulators of dopamine neurotransmission | OPRD1, OPRK1, OPRM1 | OPRM1 3/4885OPRL1 4/4885OPRD1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.