Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3948726 | 0.80 | CETP (0.45) | TSHRKMT2AMEN1ALDH1A1 | |
| SCHEMBL2916952 | 0.80 | PDE11A (0.42) | MAPTUSP2HSD17B10HPGDTSHR | |
| SCHEMBL3027474 | 0.77 | CHRNA10 (0.37) | TSHRKMT2AMEN1ALDH1A1 | |
| SCHEMBL2923250 | 0.77 | KMT2A (0.41) | MAPTUSP2HSD17B10HPGDKMT2A | |
| SCHEMBL18683972 | 0.69 | CCNA2 (0.36) | MAPTUSP2HSD17B10KMT2AMEN1 | |
| SCHEMBL3023070 | 0.65 | KARS1 (0.43) | MAPTUSP2HSD17B10HPGDTSHR | |
| SCHEMBL22495406 | 0.64 | RAB9A (0.77) | MAPTUSP2HSD17B10HPGDKMT2A | |
| SCHEMBL588747 | 0.64 | CCR1 (0.39) | MAPTTSHRKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL1663780 | 0.64 | MAPT (0.66) | MAPTHPGDKMT2AMEN1NPC1 | |
| SCHEMBL13212450 | 0.63 | ALDH1A1 (0.40) | MAPTHPGDTSHRKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874781-B9 | DIHYDROTHIENOPYRIMIDINES FOR THE TREATMENT OF INFLAMMATORY DISEASES | BOEHRINGER INGELHEIM INT (DE) | 2010-09-08 | — | — | EP | disclosed |
| EP-1874781-B1 | DIHYDROTHIENOPYRIMIDINES FOR THE TREATMENT OF INFLAMMATORY DISEASES | BOEHRINGER INGELHEIM INT (DE) | 2009-06-24 | — | — | EP | disclosed |