Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | EIF4EBP1 | Q13541 | 7/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29661920 | 0.84 | LMNA (0.37) | POLBGPR35MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL22866803 | 0.84 | LMNA (0.37) | POLBGPR35MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL28718650 | 0.79 | EIF4EBP1 (0.35) | GPR35ALDH1A1SMN1; SMN2EIF4EBP1PPARA | |
| SCHEMBL28704856 | 0.77 | EIF4EBP1 (0.41) | ALDH1A1SMN1; SMN2EIF4EBP1 | |
| SCHEMBL22866853 | 0.67 | KDM5A (0.46) | ALDH1A1SMN1; SMN2EIF4EBP1KDM4ELMNA | |
| SCHEMBL20541047 | 0.66 | POLB (0.51) | POLBMAPTALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL28906508 | 0.66 | POLB (0.51) | POLBMAPTALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL7208766 | 0.65 | EIF4EBP1 (0.46) | EIF4EBP1KDM4E | |
| SCHEMBL19554455 | 0.64 | ALDH1A1 (0.42) | GPR35ALDH1A1SMN1; SMN2EIF4EBP1KDM4E | |
| SCHEMBL9382663 | 0.63 | KEAP1 (0.58) | POLBMAPTALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114269756-B | 4-Oxo-3, 4-dihydropyrido [3,4-D ] pyrimidine compounds that inhibit EIF4E | 效应疗法股份有限公司 | 2024-05-14 | — | — | CN | disclosed |