Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 3/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22866803 | 1.00 | LMNA (0.37) | LMNATP53MAPTPOLBSMN1; SMN2 | |
| SCHEMBL29214617 | 0.84 | POLB (0.43) | LMNAMAPTPOLBSMN1; SMN2KDM4E | |
| SCHEMBL21813838 | 0.81 | KDM4E (0.43) | MAPTPOLBSMN1; SMN2KDM4ENQO2 | |
| SCHEMBL29560681 | 0.81 | KDM4E (0.43) | MAPTPOLBSMN1; SMN2KDM4ENQO2 | |
| SCHEMBL27319832 | 0.80 | NQO2 (0.39) | MAPTSMN1; SMN2KDM4EHPGDNQO2 | |
| SCHEMBL29559836 | 0.80 | NQO2 (0.39) | MAPTSMN1; SMN2KDM4EHPGDNQO2 | |
| SCHEMBL19554465 | 0.72 | KDM4E (0.43) | MAPTPOLBSMN1; SMN2KDM4ENQO2 | |
| SCHEMBL29267467 | 0.72 | SLC6A3 (0.41) | LMNATP53MAPTPOLBSMN1; SMN2 | |
| SCHEMBL24533128 | 0.71 | RAB9A (0.47) | LMNATP53MAPTPOLBSMN1; SMN2 | |
| SCHEMBL22866806 | 0.70 | PSMD14 (0.42) | MAPTPOLBSMN1; SMN2KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3994139-A1 | EIF4E-INHIBITING 4-OXO-3,4-DIHYDROPYRIDO[3,4-D]PYRIMIDINE COMPOUNDS | Effector Therapeutics Inc. (US) | 2022-05-11 | — | — | EP | disclosed |