SCHEMBL2921647

SCHEMBL2921647

O=S(=O)(Cl)c1ccc(C2CC2)cc1F

nearest known ligand 0.37

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PIK3C3 Q8NEB9 1/20 0.37
TRPV4 Q9HBA0 3/20 0.35
CNR1 P21554 1/20 0.35
WDR5 P61964 1/20 0.35
USP5 P45974 3/20 0.34
HDAC6 Q9UBN7 1/20 0.34
SCN1A P35498 1/20 0.34
SCN5A Q14524 1/20 0.34
SCN8A Q9UQD0 1/20 0.34
HSD11B1 P28845 1/20 0.33
HRH3 Q9Y5N1 1/20 0.33
PANK3 Q9H999 1/20 0.33
GRIA4 P48058 1/20 0.32
AKR1A1 P14550 1/20 0.32
AKR1B1 P15121 1/20 0.32
HCRTR2 O43614 2/20 0.32
ACLY P53396 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2746854 0.93 ACMSD (0.38) PIK3C3
SCHEMBL2925439 0.80 TRPV4 (0.47) TRPV4WDR5USP5HSD11B1
SCHEMBL2954709 0.79 WDR5 (0.40) TRPV4WDR5HSD11B1
SCHEMBL2746927 0.76 ACMSD (0.41) USP5HDAC6
SCHEMBL25318742 0.75 TRPV4 (0.58) TRPV4
SCHEMBL19682382 0.75 TRPV4 (0.39) TRPV4WDR5HCRTR2
SCHEMBL29899701 0.72 AKR1B1 (0.46) TRPV4AKR1B1ACLY
SCHEMBL113810 0.72 AKR1B1 (0.46) TRPV4AKR1B1ACLY
SCHEMBL808710 0.72 HTR2A (0.46) USP5HDAC6GRIA4HCRTR2
SCHEMBL29389392 0.72 HTR2A (0.46) USP5HDAC6GRIA4HCRTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2226312-A1 METHOD FOR PRODUCING 3-MERCAPTOANILINE COMPOUND IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 2010-09-08 EP disclosed