Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | VHL | P40337 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29223537 | 0.83 | MAPT (0.50) | CHRNB2CHRNA4POLBCHRNA7MAPT | |
| SCHEMBL30902749 | 0.83 | MAPT (0.50) | CHRNB2CHRNA4POLBCHRNA7MAPT | |
| SCHEMBL15415551 | 0.81 | CRBN (0.49) | CRBNPOLBALOX5MAPTHTT | |
| SCHEMBL2198674 | 0.70 | CRBN (0.63) | CRBNPOLBALOX5ALDH1A1MEN1 | |
| SCHEMBL30702779 | 0.70 | CRBN (0.63) | CRBNPOLBALOX5ALDH1A1MEN1 | |
| SCHEMBL15415552 | 0.68 | CRBN (0.39) | CRBNALOX5MAPTALDH1A1CYP2C19 | |
| SCHEMBL10375118 | 0.68 | CHRNB2 (0.56) | CHRNB2CHRNA4POLBCHRNA7MAPT | |
| SCHEMBL29090079 | 0.68 | CRBN (0.55) | CRBNALOX5ALDH1A1MEN1CYP2D6 | |
| SCHEMBL18124187 | 0.66 | ALDH1A1 (0.57) | CHRNB2CHRNA4CHRNA7MAPTHTT | |
| SCHEMBL27707800 | 0.66 | CYP2A6 (0.38) | CHRNB2CHRNA4POLBVHLCHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117858874-A | HPK1 degrading agents, compositions comprising the same, and methods of use thereof | 百放开曼有限公司 | 2024-04-09 | — | — | CN | disclosed |