Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30202774 | 0.74 | L3MBTL1 (0.64) | SMN1; SMN2LMNAGAAALDH1A1L3MBTL1 | |
| SCHEMBL23925146 | 0.73 | L3MBTL1 (0.49) | SMN1; SMN2LMNAGAAKDM4EALDH1A1 | |
| SCHEMBL2106013 | 0.72 | CYP1A2 (0.53) | TRPV1 | |
| SCHEMBL22635853 | 0.71 | L3MBTL1 (0.47) | SMN1; SMN2LMNAGAAKDM4EALDH1A1 | |
| SCHEMBL22635874 | 0.70 | L3MBTL1 (0.46) | SMN1; SMN2LMNAGAAKDM4ETDP1 | |
| SCHEMBL190307 | 0.70 | MAPK1 (0.59) | SMN1; SMN2LMNAGAAKDM4ETDP1 | |
| SCHEMBL21718987 | 0.69 | CYP3A4 (0.49) | SMN1; SMN2LMNAGAAKDM4ETDP1 | |
| SCHEMBL488148 | 0.68 | HSP90AA1 (0.61) | TDP1POLBHRH3HSP90AA1 | |
| SCHEMBL9279600 | 0.68 | POLB (0.52) | SMN1; SMN2LMNAGAAKDM4EALDH1A1 | |
| Alcohol SCHEMBL29233432 | 0.65 | MAPK1 (0.54) | SMN1; SMN2KDM4ETDP1POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117858874-A | HPK1 degrading agents, compositions comprising the same, and methods of use thereof | 百放开曼有限公司 | 2024-04-09 | — | — | CN | disclosed |