Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MGLL | Q99685 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ESPL1 | Q14674 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | BCL9 | O00512 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1983658 | 0.82 | TSHR (0.32) | MAPTLMNA | |
| SCHEMBL2921060 | 0.82 | TSHR (0.48) | MAPTACHEALDH1A1LMNAHTT | |
| SCHEMBL27088386 | 0.78 | TSHR (0.52) | MAPTHSD17B10HDAC3HDAC1HDAC2 | |
| Butane SCHEMBL28792796 | 0.77 | HSD17B10 (0.64) | MAPTHSD17B10ACHEALDH1A1LMNA | |
| SCHEMBL6791112 | 0.77 | POLB (0.37) | MAPTHDAC3HDAC1HDAC2LMNA | |
| SCHEMBL28262241 | 0.77 | LMNA (0.37) | MAPTALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL15648671 | 0.76 | BDKRB2 (0.36) | MAPTHSD17B10ALDH1A1LMNAHTT | |
| SCHEMBL15648819 | 0.76 | BDKRB2 (0.36) | MAPTHSD17B10ALDH1A1LMNAHTT | |
| SCHEMBL4770531 | 0.76 | PTGS2 (0.43) | SMN1; SMN2 | |
| SCHEMBL4765265 | 0.76 | ATM (0.41) | ALDH1A1LMNASMN1; SMN2LOXL2RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-9040601-A | — | — | None | — | — | JP | disclosed |
| US-8883833-B2 | Substituted benzoazole PDE4 inhibitors for treating inflammatory, cardiovascular and CNS disorders | DECODE GENETICS EHF (IS) | 2014-11-11 | — | — | US | disclosed |
| CN-101918380-B | Substituted benzoazole PDE4 inhibitors for treating inflammatory, cardiovascular and cns disorders | DECODE GENETICS EHF | 2014-09-24 | — | — | CN | disclosed |
| US-20140275553-A1 | SUBSTITUTED BENZOAZOLE PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS | DECODE GENETICS EHF (IS) | 2014-09-18 | — | — | US | disclosed |
| US-20120207729-A1 | SUBSTITUTED BENZOAZOLE PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS | DECODE GENETICS EHF (IS) | 2012-08-16 | — | — | US | disclosed |
| CN-101918381-A | Substituted benzoazole PDE4 inhibitors for treating pulmonary and cardiovascular disorders | DECODE GENETICS EHF | 2010-12-15 | — | — | CN | disclosed |
| CN-101918380-A | Substituted benzoazole PDE4 inhibitors for treating inflammatory, cardiovascular and cns disorders | DECODE GENETICS EHF | 2010-12-15 | — | — | CN | disclosed |
| EP-2225216-A1 | SUBSTITUTED BENZOAZOLE PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS | Decode Genetics EHF (IS) | 2010-09-08 | — | — | EP | disclosed |
| EP-2225215-A1 | SUBSTITUTED BENZOAZOLE PDE4 INHIBITORS FOR TREATING INFLAMMATORY, CARDIOVASCULAR AND CNS DISORDERS | Decode Genetics EHF (IS) | 2010-09-08 | — | — | EP | disclosed |
| WO-2009067604-A1 | SUBSTITUTED BENZOAZOLE PDE4 INHIBITORS FOR TREATING INFLAMMATORY, CARDIOVASCULAR AND CNS DISORDERS | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |
| US-6307045-B1 | REACTING AN ORGANOMETALLIC COMPOUND WITH A HALIDE ION UNDER LIGHT IRRADIATION CONDITIONS IN THE PRESENCE OF A SEMICONDUCTOR CATALYST WITH A PHOTOCATALYTIC ACTIVITY. | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2001-10-23 | — | — | US | disclosed |
| EP-1067103-A2 | Process for producing halogenated benzene compound | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2001-01-10 | — | — | EP | disclosed |
| US-5801168-A | NMDA RECEPTOR ANTAGONISTS | ZENECA LIMITED (GB) | 1998-09-01 | — | — | US | disclosed |
| EP-0702673-B1 | BENZ(B)AZEPINE-2,5-DIONES USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISORDERS | ZENECA LTD (GB) | 1998-02-25 | — | — | EP | disclosed |
| US-5656626-A | NERVOUS SYSTEM OR BRAIN DISORDERS; BENZ(B)AZEPINE | ZENECA LIMITED (GB) | 1997-08-12 | — | — | US | disclosed |
| JP-H0940601-A | PRODUCTION OF OPTICALLY ACTIVE KETONE DERIVATIVE AND THE SAME | NIPPON SODA CO LTD | 1997-02-10 | — | — | JP | disclosed |
| EP-0702673-A1 | BENZ(B)AZEPINE-2,5-DIONES USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISORDERS | ZENECA LIMITED (GB) | 1996-03-27 | — | — | EP | disclosed |
| US-5502048-A | CNS, STROKES, HYPOGLYCEMIC AGENTS AND ANTIISCHEMIC AGENTS | ZENECA LIMITED (GB) | 1996-03-26 | — | — | US | disclosed |
| WO-1994029275-A1 | BENZ(B)AZEPINE-2,5-DIONES USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISORDERS | ZENECA LIMITED (GB) | 1994-12-22 | — | — | WO | disclosed |
| JP-H00940601-A | — | — | 0001-01-01 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120207729-A1 | SUBSTITUTED BENZOAZOLE PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS | PDE3B, PDE4B, PDE4A | MAPT 4489/4885HSD17B10 1913/4885HDAC3 416/4885 |
| US-20140275553-A1 | SUBSTITUTED BENZOAZOLE PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS | PDE3B, PDE4B, PDE4A | MAPT 4489/4885HSD17B10 1913/4885HDAC3 416/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.