Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.36 |
| ▸ | NPR1 | P16066 | 5/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | PRKCI | P41743 | 3/20 | 0.32 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.32 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.32 |
| ▸ | IKBKB | O14920 | 1/20 | 0.31 |
| ▸ | CHUK | O15111 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2925835 | 0.81 | PDE10A (0.37) | PDE10ACDK2GSK3BMAPK14CDC7 | |
| SCHEMBL391330 | 0.80 | IRAK1 (0.41) | ADORA1ADORA2ACDK2GSK3B | |
| SCHEMBL28784139 | 0.76 | ADORA1 (0.30) | ADORA1ADORA2AMAPK14 | |
| SCHEMBL29809458 | 0.73 | PDE10A (0.48) | PDE10ACDK2GSK3BMAPK14PRKCI | |
| SCHEMBL595945 | 0.71 | MKNK1 (0.35) | ADORA1ADORA2APDE10APRKCI | |
| SCHEMBL392643 | 0.69 | BRAF (0.41) | ADORA1ADORA2A | |
| SCHEMBL388901 | 0.69 | IRAK1 (0.38) | ADORA1ADORA2ACDK2 | |
| SCHEMBL2923179 | 0.68 | TDO2 (0.39) | ADORA1ADORA2APDE10ACDK2GSK3B | |
| SCHEMBL387938 | 0.66 | SCN9A (0.38) | ADORA1ADORA2ACDK2 | |
| SCHEMBL2923633 | 0.64 | IRAK1 (0.40) | ADORA1ADORA2ACDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125793-B1 | IMIDAZOLIDINONYL AMINOPYRIMIDINE COMPOUNDS FOR THE TREATMENT OF CANCER | LILLY CO ELI (US) | 2010-09-01 | — | — | EP | claimed |