Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31023546 | 0.90 | ALDH1A1 (0.64) | NPC1GAAKMT2AMEN1EPHX2 | |
| SCHEMBL2087667 | 0.84 | PPID (0.68) | GAAKMT2AMEN1HPGDEPHX2 | |
| SCHEMBL3087061 | 0.84 | GAA (0.73) | GAAKMT2AMEN1HPGDMCL1 | |
| SCHEMBL28872153 | 0.83 | GAA (0.53) | NPC1GAAKMT2AMEN1HPGD | |
| SCHEMBL15334931 | 0.82 | MEN1 (0.59) | NPC1GAAKMT2AMEN1HPGD | |
| SCHEMBL28554545 | 0.82 | GAA (0.57) | GAATSHRCYP3A4CYP2C19SMN1; SMN2 | |
| SCHEMBL26097558 | 0.82 | LMNA (0.62) | GAAKMT2AMEN1HPGDTSHR | |
| SCHEMBL4535892 | 0.82 | MEN1 (0.59) | GAAKMT2AMEN1HPGDL3MBTL1 | |
| SCHEMBL2797868 | 0.82 | NPC1 (0.65) | NPC1GAAKMT2AMEN1HPGD | |
| SCHEMBL1232792 | 0.82 | MEN1 (0.78) | GAAKMT2AMEN1TSHREPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160362535-A1 | 5H-FURAN-2-ONE DERIVATIVES STABILIZATION OF ORGANIC MATERIAL | BASF SCHWEIZ AG (CH) | 2016-12-15 | — | — | US | disclosed |
| US-20160362535-A1 | 5H-FURAN-2-ONE DERIVATIVES STABILIZATION OF ORGANIC MATERIAL | BASF SCHWEIZ AG (CH) | 2016-12-15 | — | — | US | disclosed |
| US-9458380-B2 | 5H-furan-2-one derivatives for stabilization of organic material | BASF SE (DE) | 2016-10-04 | — | — | US | disclosed |
| US-9458380-B2 | 5H-furan-2-one derivatives for stabilization of organic material | BASF SE (DE) | 2016-10-04 | — | — | US | disclosed |
| EP-2705082-B1 | 5H-FURAN-2-ONE DERIVATIVES FOR STABILIZATION OF ORGANIC MATERIAL | BASF SE (DE) | 2015-09-23 | — | — | EP | disclosed |
| US-20140058021-A1 | 5H-Furan-2-one Derivatives for Stabilization of Organic Material | BASF SE (DE) | 2014-02-27 | — | — | US | disclosed |
| US-20140058021-A1 | 5H-Furan-2-one Derivatives for Stabilization of Organic Material | BASF SE (DE) | 2014-02-27 | — | — | US | disclosed |
| EP-1635839-B1 | BENZO[4,5]THIENO[2,3-D]PYRIMIDIN-4-ONES AND THEIR USE IN THERAPY | ABBOTT HEALTHCARE PRODUCTS BV (NL) | 2010-09-01 | — | — | EP | disclosed |
| US-7524853-B2 | Compounds and their use in therapy | SOLVAY PHARMACEUTICALS B.V. (NL) | 2009-04-28 | — | — | US | disclosed |
| US-7465739-B2 | Compounds and their use in therapy | SOLVAY PHARMACEUTICALS B.V. (NL) | 2008-12-16 | — | — | US | disclosed |
| US-7160902-B2 | Amide derivatives and methods of their use | ADOLOR CORPORATION (US) | 2007-01-09 | — | — | US | disclosed |
| US-20050176742-A1 | Novel compounds and their use in therapy | SOLVAY PHARMACEUTICALS B.V. (NL) | 2005-08-11 | — | — | US | disclosed |
| US-20050038053-A1 | Novel compounds and their use in therapy | SOLVAY PHARMACEUTICALS B.V. (NL) | 2005-02-17 | — | — | US | disclosed |
| US-4419363-A | ADRENERGIC BLOCKING AGENTS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-12-06 | — | — | US | disclosed |
| US-4346111-A | CARDIOVASCULAR DISORDERS, HYPOTENSIVE AGENTS, ADRENERGIC BLOCKING AGENTS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1982-08-24 | — | — | US | disclosed |
| US-4318921-A | HYPOTENSIVE AGENTS; ADRENERGIC BLOCKING AGENTS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1982-03-09 | — | — | US | disclosed |
| US-4211878-A | ADRENERGIC BLOCKING AGENTS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1980-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176742-A1 | Novel compounds and their use in therapy | HSD17B11, HSD17B2, HSD17B1 | NPC1 618/4885GAA 519/4885KMT2A 2945/4885 |
| US-20050038053-A1 | Novel compounds and their use in therapy | HSD17B11, HSD17B2, HSD17B1 | NPC1 618/4885GAA 519/4885KMT2A 2945/4885 |
| US-20160362535-A1 | 5H-FURAN-2-ONE DERIVATIVES STABILIZATION OF ORGANIC MATERIAL | C5, C9, CBR1 | NPC1 1612/4885GAA 4653/4885KMT2A 3534/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.