Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | GRK2 | P25098 | 1/20 | 0.52 |
| ▸ | TGM2 | P21980 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12863729 | 0.83 | GAA (0.62) | MEN1KMT2AL3MBTL1GAAALDH1A1 | |
| SCHEMBL26097558 | 0.83 | LMNA (0.62) | MEN1KMT2AGAAALDH1A1POLB | |
| SCHEMBL2797868 | 0.83 | NPC1 (0.65) | MEN1KMT2AGAAALDH1A1MAPT | |
| SCHEMBL15334931 | 0.83 | MEN1 (0.59) | MEN1KMT2AGAAALDH1A1MAPT | |
| SCHEMBL2922871 | 0.82 | NPC1 (0.59) | MEN1KMT2AL3MBTL1GAAALDH1A1 | |
| SCHEMBL2755804 | 0.80 | TSHR (0.59) | MEN1KMT2AL3MBTL1GAAALDH1A1 | |
| SCHEMBL4773621 | 0.80 | MEN1 (0.65) | MEN1KMT2AL3MBTL1GAAALDH1A1 | |
| SCHEMBL24242176 | 0.80 | L3MBTL1 (0.59) | MEN1KMT2AL3MBTL1GAAALDH1A1 | |
| SCHEMBL31023546 | 0.80 | ALDH1A1 (0.64) | MEN1KMT2AGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL28554545 | 0.79 | GAA (0.57) | GAAALDH1A1MAPTPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257539-B1 | SUBSTITUTED 4-HYDROXYPYRIMIDINE-5-CARBOXAMIDES | MERCK SHARP & DOHME (US) | 2014-09-10 | — | — | EP | disclosed |
| US-8278304-B2 | Substituted 4-hydroxypyrimidine-5-carboxamides | MERCK SHARP & DOHME CORP. (US) | 2012-10-02 | — | — | US | disclosed |
| CN-102036981-A | Substituted 4-hydroxypyrimidine-5-carboxamides | MERCK SHARP & DOHME | 2011-04-27 | — | — | CN | disclosed |
| US-20090239876-A1 | Substituted 4-Hydroxypyrimidine-5-Carboxamides | MERCK SHARP & DOHME LLC | 2009-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239876-A1 | Substituted 4-Hydroxypyrimidine-5-Carboxamides | HIF1AN, EGLN2, EGLN3 | MEN1 3663/4885KMT2A 100/4885L3MBTL1 1905/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.