Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 5/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | SCD | O00767 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1760945 | 0.89 | LMNA (0.47) | KDM4EALDH1A1LMNAGAAHTT | |
| SCHEMBL2927982 | 0.87 | ADORA2B (0.47) | KDM4EALDH1A1GAAKMT2AADORA2A | |
| SCHEMBL3041508 | 0.84 | PHGDH (0.47) | ALDH1A1LMNAGAAHTTKMT2A | |
| SCHEMBL2932276 | 0.83 | CYP2D6 (0.41) | ALDH1A1ADORA2A | |
| SCHEMBL3039094 | 0.82 | TACR1 (0.36) | ADORA2ASCD | |
| SCHEMBL2925605 | 0.82 | FAAH (0.40) | ALDH1A1LMNAGAAKMT2ADRD2 | |
| SCHEMBL2930871 | 0.82 | ADORA2A (0.49) | HTTADORA2ADRD2 | |
| SCHEMBL2931360 | 0.81 | GPR6 (0.47) | ADORA2ADRD2 | |
| SCHEMBL2932713 | 0.81 | ADORA2A (0.49) | KDM4EALDH1A1LMNAGAAHTT | |
| SCHEMBL2931382 | 0.81 | ADORA2A (0.41) | ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027132-B1 | THIAZOLO-PYRAMIDINE / PYRIDINE UREA DERIVATIVES AS ADENOSINE A2B RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-09-15 | — | — | EP | claimed |