Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR6 | P46095 | 5/20 | 0.47 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2930504 | 0.92 | FAAH (0.45) | GPR6FAAH | |
| SCHEMBL2928449 | 0.92 | GPR6 (0.46) | GPR6FAAHACHE | |
| SCHEMBL1760981 | 0.89 | FAAH (0.49) | GPR6STAT3FAAH | |
| SCHEMBL2927982 | 0.89 | ADORA2B (0.47) | KCNH2FAAHADORA2AADORA2BADORA1 | |
| SCHEMBL2925605 | 0.89 | FAAH (0.40) | GPR6DRD2DRD4FAAHACHE | |
| SCHEMBL2931169 | 0.87 | OGA (0.38) | GPR6FAAHADORA2AADORA2BADORA1 | |
| SCHEMBL3049811 | 0.87 | MEN1 (0.42) | FAAHADORA2AACHE | |
| SCHEMBL2929411 | 0.86 | ADORA2A (0.41) | ADORA2AADORA1ACHE | |
| SCHEMBL2930506 | 0.85 | GPR6 (0.38) | GPR6ACHE | |
| SCHEMBL2932276 | 0.85 | CYP2D6 (0.41) | ABL1ADORA2AADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027132-B1 | THIAZOLO-PYRAMIDINE / PYRIDINE UREA DERIVATIVES AS ADENOSINE A2B RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-09-15 | — | — | EP | claimed |