Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 6/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MPL | P40238 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7701143 | 0.73 | ALDH1A1 (0.50) | SCN9AHSD11B1CNR2POLBNPSR1 | |
| SCHEMBL30646046 | 0.73 | POLB (0.42) | SCN9AHSD11B1CNR2POLBNPSR1 | |
| SCHEMBL29244161 | 0.71 | NISCH (0.43) | SCN9A | |
| SCHEMBL29244152 | 0.70 | DYRK1A (0.43) | HSD11B1 | |
| SCHEMBL21437133 | 0.67 | SCN9A (0.48) | SCN9AHSD11B1CNR2POLBNPSR1 | |
| SCHEMBL2040458 | 0.66 | — | — | |
| SCHEMBL306822 | 0.66 | FFAR4 (0.55) | SCN9AHSD11B1TRPA1L3MBTL1ALDH1A1 | |
| SCHEMBL29788132 | 0.66 | FFAR4 (0.55) | SCN9AHSD11B1TRPA1L3MBTL1ALDH1A1 | |
| SCHEMBL4654446 | 0.66 | RXRA (0.47) | SCN9AHSD11B1POLBNPSR1TRPA1 | |
| SCHEMBL12473634 | 0.66 | ALDH1A1 (0.42) | SCN9AHSD11B1CNR2POLBNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118290434-A | Spiropiperidine derivative containing alpha-methylene-gamma-butyrolactone, preparation method and application thereof | 南开大学 | 2024-07-05 | — | — | CN | claimed |
| CN-118290434-A | Spiropiperidine derivative containing alpha-methylene-gamma-butyrolactone, preparation method and application thereof | 南开大学 | 2024-07-05 | — | — | CN | disclosed |