Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 19/20 | 1.00 |
| ▸ | THRA | P10827 | 17/20 | 1.00 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13176229 | 0.92 | THRB (0.85) | THRBTHRANR3C1 | |
| SCHEMBL13176224 | 0.88 | THRB (0.79) | THRBTHRA | |
| SCHEMBL2928572 | 0.86 | THRB (1.00) | THRBTHRA | |
| SCHEMBL2928883 | 0.84 | THRB (0.72) | THRBTHRA | |
| SCHEMBL2927243 | 0.81 | THRB (0.68) | THRBTHRA | |
| SCHEMBL2928910 | 0.78 | THRB (1.00) | THRBTHRA | |
| SCHEMBL21749446 | 0.75 | THRB (0.59) | THRBTHRA | |
| SCHEMBL13116435 | 0.74 | THRB (0.76) | THRBTHRA | |
| SCHEMBL13116389 | 0.74 | THRB (0.78) | THRBTHRA | |
| SCHEMBL2929101 | 0.74 | THRB (0.68) | THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919878-B1 | PYRIDAZINONE DERIVATIVES AS THYROID HORMONE RECEPTOR AGONISTS | HOFFMANN LA ROCHE (CH) | 2010-09-08 | — | — | EP | claimed |
| EP-1919878-A1 | PYRIDAZINONE DERIVATIVES AS THYROID HORMONE RECEPTOR AGONISTS | F. Hoffmann-Roche AG (CH) | 2008-05-14 | — | — | EP | claimed |
| WO-2007009913-A1 | PYRIDAZINONE DERIVATIVES AS THYROID HORMONE RECEPTOR AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-01-25 | — | — | WO | claimed |
| US-RE46024-E1 | Thyroid hormone analogs | HOFFMANN-LA ROCHE INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-RE46024-E1 | Thyroid hormone analogs | HOFFMANN-LA ROCHE INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-RE46024-E1 | Thyroid hormone analogs | HOFFMANN-LA ROCHE INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-8399001-B2 | Stabilizing compositions in suspension; fixing and holding the hair, a hair conditioner giving the hair softness, and a hair makeup | L'OREAL (FR) | 2013-03-19 | — | — | US | disclosed |
| EP-1532968-B1 | Cosmetic composition comprising gellan gum or a derivative thereof, a monovalent salt and a compound in suspension, process using this composition and uses thereof | OREAL (FR) | 2013-03-13 | — | — | EP | disclosed |
| EP-2246040-A2 | Method for the shaping of hair including a step of applying a reducing composition and a heating step | L'Oréal (FR) | 2010-11-03 | — | — | EP | disclosed |
| US-7807674-B2 | Thyroid hormone analogs | HOFFMANN-LA ROCHE INC. (US) | 2010-10-05 | — | — | US | disclosed |
| US-7807674-B2 | Thyroid hormone analogs | HOFFMANN-LA ROCHE INC. (US) | 2010-10-05 | — | — | US | disclosed |
| EP-1652510-A1 | Cosmetic composition comprising a sulfonic polyester and a polyurethane | L'OREAL (FR) | 2006-05-03 | — | — | EP | disclosed |
| EP-1629827-A1 | Cosmetic composition comprising a linear sulfonic polyester and a modified guar gum | L'OREAL (FR) | 2006-03-01 | — | — | EP | disclosed |
| EP-1629828-A1 | Cosmetic composition comprising a linear sulfonic polyester and a specific polyurethane | L'OREAL (FR) | 2006-03-01 | — | — | EP | disclosed |
| US-20060024261-A1 | Cosmetic compositions comprising a linear sulfonic polyester and a polyurethane, processes using these compositions and uses thereof | L'OREAL S.A. (FR) | 2006-02-02 | — | — | US | disclosed |
| WO-2005092275-A1 | COSMETIC COMPOSITION COMPRISING A DENDRITIC POLYMER WITH PERIPHERAL FATTY CHAINS, A SURFACTANT AND A COSMETIC AGENT, AND USES THEREOF | L'OREAL (FR) | 2005-10-06 | — | — | WO | disclosed |
| US-20050196368-A1 | Cosmetic composition comprising at least one anionic fixing polymer and at least one nonionic compound, and a process for shaping keratin fibers therewith by applying heat | L'OREAL S.A. (FR) | 2005-09-08 | — | — | US | disclosed |
| EP-1566165-A1 | Process for the shaping of keratin fibers with a composition comprising an anionic fixative polymer and a non-ionic compound and using heating means | L'OREAL (FR) | 2005-08-24 | — | — | EP | disclosed |
| US-20050169869-A1 | Cosmetic composition comprising at least one gellan gum or derivative thereof, at least one monovalent salt, and at least one suspension compound, processes using this composition, and uses thereof | L'OREAL | 2005-08-04 | — | — | US | disclosed |
| EP-1532968-A1 | Cosmetic composition comprising gellan gum or a derivative thereof, a monovalent salt and a compound in suspension, process using this composition and uses thereof | L'OREAL (FR) | 2005-05-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050196368-A1 | Cosmetic composition comprising at least one anionic fixing polymer and at least one nonionic compound, and a process for shaping keratin fibers therewith by applying heat | KRT18, CUTA, INHA | THRB 3284/4885THRA 2252/4885NR3C1 4561/4885 |
| US-20060024261-A1 | Cosmetic compositions comprising a linear sulfonic polyester and a polyurethane, processes using these compositions and uses thereof | CUTA, FHIT, POLR1C | THRB 4507/4885THRA 3816/4885NR3C1 4802/4885 |
| US-20050169869-A1 | Cosmetic composition comprising at least one gellan gum or derivative thereof, at least one monovalent salt, and at least one suspension compound, processes using this composition, and uses thereof | ALG3, GYPA, ALG1 | THRB 2930/4885THRA 1743/4885NR3C1 776/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.