Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 14/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 13/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 13/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1761027 | 0.88 | ADORA2B (0.46) | ADORA2BADORA2AADORA1RIPK1 | |
| SCHEMBL2931791 | 0.87 | RPS6KB1 (0.37) | ADORA2BADORA2AADORA1 | |
| SCHEMBL1760886 | 0.84 | ADORA2B (0.51) | ADORA2BADORA2AADORA1 | |
| SCHEMBL2931875 | 0.84 | ALDH1A1 (0.40) | ADORA2AADORA1KDM4E | |
| SCHEMBL2927982 | 0.84 | ADORA2B (0.47) | ADORA2BADORA2AADORA1KDM4E | |
| SCHEMBL2930871 | 0.81 | ADORA2A (0.49) | ADORA2BADORA2AADORA1 | |
| SCHEMBL3041508 | 0.81 | PHGDH (0.47) | ADORA2ASCN9A | |
| SCHEMBL2928074 | 0.80 | ADORA2A (0.51) | ADORA2BADORA2AADORA1 | |
| SCHEMBL2932934 | 0.80 | ADORA2B (0.40) | ADORA2BADORA2AADORA1KDM4E | |
| SCHEMBL2929521 | 0.80 | ADORA2A (0.38) | ADORA2BADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027132-B1 | THIAZOLO-PYRAMIDINE / PYRIDINE UREA DERIVATIVES AS ADENOSINE A2B RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-09-15 | — | — | EP | claimed |