Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | LPL | P06858 | 1/20 | 0.34 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.34 |
| ▸ | CCR3 | P51677 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2929995 | 0.90 | ADORA2A (0.37) | RPS6KB1ADORA2AADORA1CCR3CCR5 | |
| SCHEMBL2931875 | 0.90 | ALDH1A1 (0.40) | ADORA2AADORA1 | |
| SCHEMBL1760897 | 0.87 | ADORA2A (0.41) | RPS6KB1TRPV1HIF1AEPAS1ADORA2B | |
| SCHEMBL2925314 | 0.87 | ADORA2B (0.42) | ADORA2BADORA2AADORA1 | |
| SCHEMBL2930816 | 0.86 | STAT3 (0.40) | CCR3CCR5 | |
| SCHEMBL2931211 | 0.83 | PDE10A (0.43) | TRPV1ADORA2APIK3CD | |
| SCHEMBL2930871 | 0.79 | ADORA2A (0.49) | TRPV1ADORA2BADORA2AADORA1 | |
| SCHEMBL2931938 | 0.79 | PIK3CD (0.37) | TRPV1ADORA2BADORA2AADORA1PIK3CD | |
| SCHEMBL2927299 | 0.79 | PIK3CG (0.36) | ADORA2BADORA2AADORA1PIK3CD | |
| SCHEMBL2932276 | 0.78 | CYP2D6 (0.41) | TRPV1ADORA2BADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027132-B1 | THIAZOLO-PYRAMIDINE / PYRIDINE UREA DERIVATIVES AS ADENOSINE A2B RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-09-15 | — | — | EP | claimed |