Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 11/20 | 0.51 |
| ▸ | ADORA2B | P29275 | 10/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 10/20 | 0.51 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ELOVL6 | Q9H5J4 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | SPR | P35270 | 1/20 | 0.36 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1761064 | 0.89 | ADORA2A (0.63) | ADORA2AADORA2BADORA1KCNQ1CTSS | |
| SCHEMBL2930871 | 0.86 | ADORA2A (0.49) | ADORA2AADORA2BADORA1 | |
| SCHEMBL2932239 | 0.84 | LMNA (0.37) | ADORA2AADORA2BADORA1KCNQ1 | |
| SCHEMBL2930544 | 0.84 | GHSR (0.36) | ADORA2AADORA1KCNQ1POLB | |
| SCHEMBL3041508 | 0.83 | PHGDH (0.47) | ADORA2APOLB | |
| SCHEMBL2932713 | 0.82 | ADORA2A (0.49) | ADORA2AADORA2BADORA1POLB | |
| SCHEMBL2931382 | 0.82 | ADORA2A (0.41) | ADORA2AADORA2BADORA1 | |
| SCHEMBL2927982 | 0.81 | ADORA2B (0.47) | ADORA2AADORA2BADORA1 | |
| SCHEMBL2925314 | 0.80 | ADORA2B (0.42) | ADORA2AADORA2BADORA1 | |
| SCHEMBL2930106 | 0.80 | ADORA2A (0.41) | ADORA2AADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027132-B1 | THIAZOLO-PYRAMIDINE / PYRIDINE UREA DERIVATIVES AS ADENOSINE A2B RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-09-15 | — | — | EP | claimed |