SCHEMBL29256271

SCHEMBL29256271

[CH2]C(O)C(=O)c1ccccc1C(F)(F)F

nearest known ligand 0.53

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.53
GAA P10253 1/20 0.53
CTNNB1 P35222 3/20 0.44
WNT3A P56704 3/20 0.44
CNR2 P34972 2/20 0.43
PPIA P62937 1/20 0.42
PTPRC P08575 1/20 0.41
PTGS1 P23219 1/20 0.41
KCNK3 O14649 1/20 0.41
KCNK9 Q9NPC2 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
NFKB1 P19838 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10137791 0.79 LMNA (0.55) LMNAGAACTNNB1WNT3ACNR2
SCHEMBL3396782 0.79 LMNA (0.55) LMNAGAACTNNB1WNT3ACNR2
SCHEMBL18409717 0.79 CES2 (0.53) LMNAGAACTNNB1WNT3ACNR2
SCHEMBL680608 0.79 LMNA (0.52) LMNAGAACTNNB1WNT3ACNR2
SCHEMBL4710154 0.78 LMNA (0.53) LMNAGAACTNNB1WNT3ACNR2
SCHEMBL19863249 0.76 LMNA (0.51) LMNAGAACTNNB1WNT3ACNR2
SCHEMBL2027517 0.76 LMNA (0.51) LMNAGAACTNNB1WNT3ACNR2
SCHEMBL29410859 0.76 LMNA (0.51) LMNAGAACTNNB1WNT3ACNR2
SCHEMBL27587010 0.76 MAPT (0.56) LMNASMN1; SMN2
SCHEMBL513651 0.76 LMNA (0.60) LMNAGAACTNNB1WNT3ACNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118159542-A Substituted 2, 3-dihydro [1,3] thiazolo [4,5-b ] pyridines, salts thereof and their use as herbicidal agents 拜耳公司 2024-06-07 CN claimed
CN-118159542-A Substituted 2, 3-dihydro [1,3] thiazolo [4,5-b ] pyridines, salts thereof and their use as herbicidal agents 拜耳公司 2024-06-07 CN disclosed