Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 8/20 | 0.57 |
| ▸ | CA12 | O43570 | 2/20 | 0.57 |
| ▸ | CA1 | P00915 | 2/20 | 0.57 |
| ▸ | CA2 | P00918 | 2/20 | 0.57 |
| ▸ | CA3 | P07451 | 2/20 | 0.57 |
| ▸ | CA4 | P22748 | 2/20 | 0.57 |
| ▸ | CA6 | P23280 | 2/20 | 0.57 |
| ▸ | CA5A | P35218 | 2/20 | 0.57 |
| ▸ | CA7 | P43166 | 2/20 | 0.57 |
| ▸ | CA9 | Q16790 | 2/20 | 0.57 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.57 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL22494138 | 1.00 | DNM1 (0.57) | DNM1CA12CA1CA2CA3 | |
| Piperazine SCHEMBL9562685 | 0.96 | NFKB1 (0.54) | DNM1CA12CA1CA2CA3 | |
| Piperazine SCHEMBL27286374 | 0.86 | DNM1 (0.68) | DNM1CA12CA1CA2CA3 | |
| Piperidine SCHEMBL28041935 | 0.84 | ALDH1A1 (0.53) | DNM1CA12CA1CA2CA3 | |
| Octadecylamine SCHEMBL13739812 | 0.82 | DNM1 (0.72) | DNM1CA12CA1CA2CA3 | |
| Piperazine SCHEMBL13281519 | 0.82 | DNM1 (0.63) | DNM1CA12CA1CA2CA3 | |
| Aziridine SCHEMBL28298746 | 0.82 | DNM1 (0.72) | DNM1CA12CA1CA2CA3 | |
| Dodecylamine SCHEMBL28300174 | 0.82 | DNM1 (0.72) | DNM1CA12CA1CA2CA3 | |
| Decylamine SCHEMBL28298672 | 0.82 | DNM1 (0.72) | DNM1CA12CA1CA2CA3 | |
| Piperazine SCHEMBL14739784 | 0.81 | HIF1A (0.55) | HIF1AMAPTPDE4AKDRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7163996-B2 | Polyamides | HENKEL CORPORATION (US) | 2007-01-16 | — | — | US | claimed |
| US-20050228165-A1 | Hot melt adhesives with solvent resistane made of polyamides from diacids and diamines with one heterocyclic diamine or a branched diamine | Henkel IP & Holding GmbH (DE) | 2005-10-13 | — | — | US | claimed |
| EP-1533330-A1 | Polyamides | Henkel KGaA (DE) | 2005-05-25 | — | — | EP | claimed |
| CN-108602688-A | METHOD FOR PRODUCING VANADIUM DIOXIDE PARTICLES | 柯尼卡美能达株式会社 | 2018-09-28 | — | — | CN | disclosed |
| EP-1533330-B1 | Polyamides | HENKEL AG & CO KGAA (DE) | 2010-09-29 | — | — | EP | disclosed |
| US-7163996-B2 | Polyamides | HENKEL CORPORATION (US) | 2007-01-16 | — | — | US | disclosed |
| US-20050228165-A1 | Hot melt adhesives with solvent resistane made of polyamides from diacids and diamines with one heterocyclic diamine or a branched diamine | Henkel IP & Holding GmbH (DE) | 2005-10-13 | — | — | US | disclosed |
| EP-1533330-A1 | Polyamides | Henkel KGaA (DE) | 2005-05-25 | — | — | EP | disclosed |
| EP-0142618-A2 | Water-thinnable polyamides | Union Camp Corporation (US) | 1985-05-29 | — | — | EP | disclosed |
| US-4514540-A | FLEXOGRAPHIC INK | UNION CAMP CORPORATION (US) | 1985-04-30 | — | — | US | disclosed |